SKIN WOUND-ENHANCED SURVIVAL AND MYELOCYTOPOIESIS IN MICE AFTER WHOLE-BODY IRRADIATION
SKIN WOUND-ENHANCED SURVIVAL AND MYELOCYTOPOIESIS IN MICE AFTER WHOLE-BODY IRRADIATION
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DOI：
10.3109/02841868109130187
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
SHEEHY, PA
中科院分区：
文献类型：
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作者：
LEDNEY, GD;STEWART, DA;SHEEHY, PA
在对小鼠进行全身 60Co 照射前 24 小时，皮肤受伤将 LD50/30 从 8.09 Gy 提高至 9.71 Gy [灰色]，导致剂量减少因子为 1.2。在 7 Gy 后第 3、7、10 和 14 天、7 Gy 前 24 小时皮肤受伤以及对照未治疗小鼠中检查骨髓增殖细胞的浓度和数量。辐射前受伤会引起骨髓和脾脏克隆细胞的增加，这种增加比辐射小鼠的增加更早且更多。在照射前受伤的动物中发现了超正常水平的脾克隆形成。 M-CFC [克隆性骨髓细胞] 值自始至终都降低，但联合受伤动物的 M-CFC 值比受辐射小鼠的值要高。
Skin wounding at 24 h before whole-body 60Co irradiation of mice raised the LD50/30 from 8.09 to 9.71 Gy [gray] resulting in a dose reduction factor of 1.2. Concentrations and quantities of myeloproliferative cells were examined at 3, 7, 10 and 14 days after 7 Gy, skin wounding 24 h before 7 Gy and in control non-treated mice. Wounding before irradiation provoked an increase in marrow and splenic clonogenic cells that was earlier and greater than that noted for irradiated mice. Supranormal levels of splenic clonogenic were found in animals wounded before irradiation. M-CFC [clonogenic myelocytes] values were depressed throughout, although greater for combined injured animals than for irradiated mice.