Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia.
Cell Fate Decisions: The Role of Transcription Factors in Early B-cell Development and Leukemia.
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DOI：
10.1158/2643-3230.bcd-20-0011
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发表时间：
2020-11
影响因子：
11.2
通讯作者：
Sánchez-García I
中科院分区：
文献类型：
--
作者：
Fischer U;Yang JJ;Ikawa T;Hein D;Vicente-Dueñas C;Borkhardt A;Sánchez-García I
B细胞是适应性免疫系统的组成部分，并调节先天免疫。它们来源于造血干细胞，通过一系列细胞命运决定而成熟。复杂的转录回路在这些谱系限制期间动态地形成和消散。相关转录因子的基因组畸变是各种B细胞疾病的基础。获得性体细胞畸变与癌症有关，而种系变异则易患恶性和非恶性疾病。我们回顾了转录因子在健康和疾病中B细胞发育过程中的作用。我们专注于早期B细胞白血病，并讨论新的致病基因-环境合作及其对精准医学的影响。
B-cells are an integral part of the adaptive immune system and regulate innate immunity. Derived from hematopoietic stem cells they mature through a series of cell fate decisions. Complex transcriptional circuits form and dissipate dynamically during these lineage restrictions. Genomic aberrations of involved transcription factors underlie various B–cell disorders. Acquired somatic aberrations are associated with cancer, whereas germline variations predispose to both malignant and non-malignant diseases. We review the opposing role of transcription factors during B-cell development in health and disease. We focus on early B-cell leukemia and discuss novel causative gene-environment cooperations and their implications for precision medicine.