Relationship between cortisol and age-related memory impairments in Holocaust survivors with PTSD.
Relationship between cortisol and age-related memory impairments in Holocaust survivors with PTSD.
复制标题
患有创伤后应激障碍的大屠杀幸存者皮质醇与年龄相关记忆障碍之间的关系。
DOI：
10.1016/j.psyneuen.2005.02.007
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Tischler,Lisa
中科院分区：
文献类型：
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作者：
Yehuda,Rachel;Golier,JuliaA;Harvey,PhilipD;Stavitsky,Karina;Kaufman,Shira;Grossman,RobertA;Tischler,Lisa
RATIONALEHolocaust survivors with PTSD appear to show an accelerated aging effect as evidenced by their performance on tests of explicit memory, and also show more exaggerated patterns on age-related alterations in cortisol release over the diurnal cycle than Holocaust survivors without PTSD and nonexposed subjects. To investigate the implications of age-related HPA axis alterations on cognition, we examined correlations between parameters reflecting circadian cortisol release and implicit and explicit memory performance.METHODSNineteen Holocaust survivors with PTSD (7 men, 12 women), 16 Holocaust survivors without PTSD (7 men, 9 women), and 28 non-exposed healthy comparison subjects (13 men, 15 women) collected salivary samples at six times over the diurnal cycle, and were tested with Paired Associates and Word Stem Completion Tests.RESULTSNegative correlations were observed between several measures of salivary cortisol concentrations and explicit memory in Holocaust survivors with PTSD after adjusting for IQ, years of education and current age reflecting poorer performance in association with higher cortisol levels. This relationship was absent in Holocaust survivors without PTSD and in demographically-comparable subjects who were not exposed to the Holocaust or other extremely traumatic events.CONCLUSIONThe significantly different relationship between cortisol and memory performance in these groups suggests that the neuropsychological impairments observed in Holocaust survivors with PTSD may reflect an interaction of PTSD and aging effects.
