REPLACEMENT OF DISEASED MOUSE-LIVER BY HEPATIC CELL TRANSPLANTATION
REPLACEMENT OF DISEASED MOUSE-LIVER BY HEPATIC CELL TRANSPLANTATION
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DOI：
10.1126/science.8108734
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发表时间：
1994-02-25
期刊：
影响因子：
56.9
通讯作者：
BRINSTER, RL
中科院分区：
文献类型：
--
作者：
RHIM, JA;SANDGREN, EP;BRINSTER, RL
成年肝脏具有在损伤后完全再生的非凡能力。尽管再生是通过成熟肝细胞的分裂来实现的，但这些细胞的复制潜能尚不清楚。在此，通过将成年小鼠肝细胞转移到在肝脏生长潜能和功能方面存在内源性缺陷的转基因小鼠中，研究了成年肝细胞的复制能力以及它们作为移植供体细胞的医学用途。移植的肝细胞群取代了患病受体肝脏多达80%的部分。这些发现证明了成年肝细胞巨大的生长潜能，表明肝细胞移植作为一种替代受损或患病肝实质的方法是可行的。
Adult liver has the unusual ability to fully regenerate after injury. Although regeneration is accomplished by the division of mature hepatocytes, the replicative potential of these cells is unknown. Here, the replicative capacity of adult liver cells and their medical usefulness as donor cells for transplantation were investigated by transfer of adult mouse liver cells into transgenic mice that display an endogenous defect in hepatic growth potential and function. The transplanted liver cell populations replaced up to 80 percent of the diseased recipient liver. These findings demonstrate the enormous growth potential of adult hepatocytes, indicating the feasibility of liver cell transplantation as a method to replace lost or diseased hepatic parenchyma.