Nuclear lamins in cancer.
Nuclear lamins in cancer.
复制标题
DOI：
10.1007/s12195-016-0437-8
复制
发表时间：
2016-06
影响因子：
2.8
通讯作者：
Discher DE
中科院分区：
文献类型：
--
作者：
Irianto J;Pfeifer CR;Ivanovska IL;Swift J;Discher DE
畸形核在癌症中很常见，这为研究癌症中核的主要结构蛋白——核层蛋白提供了强有力的动力。过去的研究也证明了微环境力学对癌症进展的重要性，这是非常有趣的，因为最近发现椎板是机械敏感的。在这里，我们回顾了目前有关癌症进展与板层生物物理学的知识。层粘连蛋白水平可以限制癌细胞在3D中的迁移，从而阻碍肿瘤的生长，层粘连蛋白还可以保护癌细胞的基因组。此外，层粘连蛋白可以影响层粘连结构域的转录调控因子（RAR， SRF, YAP/TAZ）和染色体构象。进一步研究层粘连蛋白在癌症甚至DNA损伤中的作用可能会导致新的治疗方法，或者至少更清楚地了解层粘连蛋白在癌症进展中的生物标志物作用。
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics. Lamin levels can constrain cancer cell migration in 3D and thereby impede tumor growth, and lamins can also protect a cancer cell's genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) and chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.