Preliminary Genome-Wide Association Study of Bipolar Disorder in the Japanese Population
Preliminary Genome-Wide Association Study of Bipolar Disorder in the Japanese Population
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DOI：
10.1002/ajmg.b.30941
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发表时间：
2009-12-05
影响因子：
2.8
通讯作者：
Yoshikawa, Takeo
中科院分区：
文献类型：
--
作者：
Hattori, Eiji;Toyota, Tomoko;Yoshikawa, Takeo
基因分型技术和公共数据库的发展的最新进展使得大规模全基因组与疾病的关联测试成为可能。我们在日本队列中进行了双相情感障碍 (BD) 的两阶段全基因组关联研究 (GWAS)。首先，我们使用 Affymetrix 100K GeneChip 芯片分析了 107 例 I 型双相情感障碍患者和 107 例对照者，并选择了名义上显着的标记（P
Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genome-wide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P