Epicardial Application of Hydrogel with Amiodarone for Prevention of Postoperative Atrial Fibrillation in Patients After Coronary Artery Bypass Grafting
Epicardial Application of Hydrogel with Amiodarone for Prevention of Postoperative Atrial Fibrillation in Patients After Coronary Artery Bypass Grafting
复制标题
DOI：
10.1007/s12265-019-09905-1
复制
发表时间：
2020-04-01
影响因子：
3.4
通讯作者：
Bockeria, L. A.
中科院分区：
文献类型：
--
作者：
Bockeria, O. L.;Kanametov, T. N.;Bockeria, L. A.
本研究旨在评估冠状动脉旁路移植术后患者心外膜局部应用胺碘酮释放水凝胶预防术后房颤（POAF）的安全性和有效性。将患者随机分为两组：应用胺碘酮释放水凝胶和对照组。纳入60例患者（47例男性，13例女性）（平均年龄62 ± 8.5岁）。两组间POAF发生率差异有统计学意义：研究组POAF发生率为3.3%，而对照组POAF发生率为37%（p < 0.001）。PQ间期持续时间显示统计学显著差异。使用考克斯回归模型计算POAF发生率的风险：年龄和胺碘酮释放水凝胶应用具有统计学显著性。两组患者住院时间差异有统计学意义（P < 0.001）。年龄和胺碘酮释放水凝胶的应用对POAF的发生率有统计学意义。
The objective of this study was to assess the safety and efficacy of local epicardial application of amiodarone-releasing hydrogel for prevention of postoperative atrial fibrillation (POAF) in patients after coronary artery bypass grafting. Patients were randomized into two groups: with the application of amiodarone-releasing hydrogel and the control group. It included 60 patients (47 males, 13 females) (mean age of 62 +/- 8.5). POAF incidence differences were statistically significant between two groups: in the study group, the POAF incidence was 3.3%, while in the control group, the POAF incidence was 37% (p < 0.001). Statistically significant differences were revealed in the PQ interval duration. The risk of POAF incidence was calculated using the Cox regression model: the age and the application of amiodarone-releasing hydrogel application were statistically significant. Hospital length of stay in two groups was also different (p < 0.001). The age and the application of amiodarone-releasing hydrogel were statistically significant for POAF incidence.