Immune responses in nonhaired mice.
Immune responses in nonhaired mice.
复制标题
无毛小鼠的免疫反应。
DOI：
10.1159/000233027
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Linna,TJ
中科院分区：
文献类型：
--
作者：
Smith,SM;Forbes,PD;Linna,TJ
10个股票和品系的遗传无毛小鼠进行了评估的能力，以应对两个有丝分裂原（刀豆球蛋白A和脂多糖）和两个抗原（绵羊红细胞和肺炎球菌多糖，III型）。采用免疫荧光技术测定了个体动物胸腺、脾脏和合并淋巴结中的T和B淋巴细胞数量;发现各组动物的数值相当。通过测定用任一抗原免疫后脾脏中噬斑形成细胞的数量来评价抗体形成能力。所有品系的小鼠都对这两种抗原有反应，并对反应进行了讨论。所有组的小鼠对所测试的促分裂剂都有反应。
Ten stocks and strains of genetically nonhaired mice were evaluated for the ability to respond to two mitogens (concanavalin A and lipopolysaccharide) and to two antigens (sheep erythrocytes and pneumococcal polysaccharide, type III). The numbers of T and B lymphocytes in the thymus, spleen and pooled lymph nodes of individual animals were determined using immunofluorescent techniques; the values for each group of animals were found to be comparable. The antibody-forming ability was evaluated by determining the number of plaque-forming cells in the spleen after immunization with either antigen. All strains of mice responded to both antigens and the responses are discussed. All groups of mice responded to the mitogens tested.