EFFECT OF QUESTIONNAIRE DESIGN ON RECALL OF DRUG EXPOSURE IN PREGNANCY
EFFECT OF QUESTIONNAIRE DESIGN ON RECALL OF DRUG EXPOSURE IN PREGNANCY
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DOI：
10.1093/oxfordjournals.aje.a114286
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发表时间：
1986-04-01
影响因子：
5
通讯作者：
SHAPIRO, S
中科院分区：
文献类型：
--
作者：
MITCHELL, AA;COTTLER, LB;SHAPIRO, S
产前药物暴露和出生缺陷的病例对照研究通常依赖于母亲对怀孕期间药物使用的回忆。病例和对照母亲之间的不同回忆可能导致信息偏差（“母亲回忆偏差”），并且随着对药物暴露的确定减少，这种偏差的机会增加。两项研究探讨了问卷设计对确定妊娠期药物使用情况的影响。在一项对532名产科/妇科妇女进行的试点访谈研究中，通过依次提出三个问题获得了过去一年的药物使用信息：第一个问题是开放式的，第二个问题是关于选定适应症的药物使用情况，第三个问题是关于特定药物的使用情况。在报告使用五种药物中的任何一种的产科患者中，不到50%的人回答了开放式问题，大约20-40%的人只在被问及具体药物名称时才报告使用。在一项对5435名畸形儿童母亲的病例对照出生缺陷研究中，通过按顺序询问适应症和具体命名的药物，获得了怀孕期间药物使用的信息。在报告使用11种药物中的任何一种的妇女中，只有当被问及具体药物的名称时，6-40%的妇女才这样做。这些发现表明，确定产前药物暴露的完整性因母亲被询问的方式而异，并与所问问题的特异性直接相关。
Case-control studies of antenatal drugs exposure and birth defects often rely on maternal recall of drug use in pregnancy. Differential recall among mothers of cases and controls can lead to information bias ("maternal recall bias"), and the opportunity for such bias increases as ascertainment of drug exposure diminishes. The effect of questionnaire design on the ascertainment of drug use in pregnancy was examined in two studies. In a pilot interview study of 532 women in obstetric/gynecologic practices, information on drug use in the past year was obtained by means of three questions asked in sequence: The first question was open-ended, the second asked about drug use for selected indications, and the third asked about use of specifically named drugs. Among obstetric patients who reported use of any of five drugs, less than 50% did so in response to the open-ended question, and approximately 20-40% reported use only when the specific drug name was asked. In a case-control Birth Defects Study of 5,435 mothers of malformed children, information on drug use in pregnancy was obtained by asking questions in sequence about indications and specifically named drugs. Among the women who reported use of any of 11 drugs, 6-40% did so only when asked about the specific drug by name. These findings suggest that completeness of ascertainment of antenatal drug exposure varies according to how the mother is questioned and is directly related to the specificity of the questions asked.