PHOTOSENSITIZATION OF HUMAN GLIOMA-CELLS BY CHALCOGENAPYRYLIUM DYES
PHOTOSENSITIZATION OF HUMAN GLIOMA-CELLS BY CHALCOGENAPYRYLIUM DYES
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DOI：
10.1007/bf00165102
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发表时间：
1989-07-01
影响因子：
3.9
通讯作者：
WATKINS, PJ
中科院分区：
文献类型：
--
作者：
POWERS, SK;WALSTAD, DL;WATKINS, PJ
研究了可被红光和近红外光(600-900 nm)特异性激活的硫化银染料作为光敏剂用于恶性胶质瘤的光化学治疗。对11种化学结构和氧化还原电位不同的CP染料在光激活前后对胶质瘤和正常皮肤成纤维细胞的选择性毒性进行了评价。在11种CP染料中，有8种对成纤维细胞有不同的毒性，染料浓度为1.0um。在黑暗中和激光激活后，均表现出剂量依赖性的毒性。其中两种CP染料经800 nm光活化后，其毒性显著增强。CP染料的最大吸收波长在775~850 nm之间，对脑组织具有良好的透光性，有望成为治疗脑部恶性肿瘤的光敏剂。
Chalcogenapyrylium (CP) dyes which are specifically activated by red and near infrared light (600-900 nm) were examined as potential photosensitizers for photochemotherapy of malignant gliomas. Eleven CP dyes of varying chemical structure and redox potential were evaluated for selective toxicity against glioma and normal skin fibroblast cell cultures both before and after light activation. Eight of eleven CP dyes exhibited differential toxicity to tumor over fibroblast cells at dye concentrations of 1.0 .mu.M. Dose dependent toxicity was seen both in the dark and after laser light activation. The toxicity of two of the CP dyes significantly enhanced by photoactivation with 800 nm light. The CP dyes that absorb light maximally between 775 and 850 nm, in the range of excellent light penetration through brain, appear to be promising candidates as photosensitizers for treating malignant brain tumors.