Ambient desorption ionization mass spectrometry
Ambient desorption ionization mass spectrometry
复制标题
DOI：
10.1016/j.trac.2008.01.010
复制
发表时间：
2008-04-01
影响因子：
13.1
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
--
作者：
Venter, Andre;Nefliu, Marcela;Cooks, R. Graham
环境解吸电离质谱仪(MS)允许在实验室的开放大气或其自然环境中直接分析普通物体。分析物解吸通常伴随着电离步骤，这些过程通常是协调的、多步骤的过程。自2004年引入解吸电喷雾电离(DESI[Z.Takats，J.M.Wiseman，B.Gologan，R.G.Coks，Science(Washington，D.Q 306(2004)471])和实时直接分析(DART[R.B.Cody，J.A.Laramee，H.D.Durst，ANAL.化学。77(2005)2297])2005年，多发性硬化症这个新领域得到了迅速发展。已经证明了分析物解吸和电离的各种选择的许多排列。脱附步骤，如动量转移、溶解成反弹液滴和热脱附，与电离步骤相结合，包括ESI、大气压化学电离和光致电离。已经应用的大量可能的解吸和电离成分的组合正在创造越来越复杂的技术和缩略语的扩散。在这里，我们提供了一个逻辑框架来分类这些相关的实验，基于每个实验中涉及的解吸和电离过程。(C)2008爱思唯尔有限公司。保留所有权利。
Ambient desorption ionization mass spectrometry (MS) allows for the direct analysis of ordinary objects in the open atmosphere of the laboratory or in their natural environment. Analyte desorption usually accompanies the ionization step and these processes are often concerted, multi-step processes. Ambient desorption ionization methods typically require little or no sample preparation, offer a much simplified work flow and deliver unprecedented ease of use to MS analyses.Since the introduction of desorption electrospray ionization (DESI [Z. Takats, J.M. Wiseman, B. Gologan, R.G. Cooks, Science (Washington, D. Q 306 (2004) 471]) in 2004 and the direct analysis in real time (DART [R.B. Cody, J.A. Laramee, H.D. Durst, Anal. Chem. 77 (2005) 2297]) in 2005, this new field of MS has developed rapidly. Numerous permutations of the various options for analyte desorption and ionization have been demonstrated. Desorption steps, such as momentum transfer, dissolution into ricocheting droplets and thermal desorption, have been combined with ionization steps, including ESI, atmospheric pressure chemical ionization and photo-ionization. The large number of possible combinations of desorption and ionization components that have already been applied is creating a proliferation of techniques and acronyms that is becoming ever more complex.Here, we provide a logical framework for the classification of these related experiments, based on the desorption and ionization processes involved in each. (C) 2008 Elsevier Ltd. All rights reserved.