Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
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DOI：
10.1016/j.jalz.2015.08.003
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发表时间：
2016-02-01
影响因子：
14
通讯作者：
Blennow, Kaj
中科院分区：
文献类型：
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作者：
Duits, Flora H.;Martinez-Lage, Pablo;Blennow, Kaj
简介：腰椎穿刺（LP）越来越多地在记忆诊所进行。我们调查了患者接受LP，发病率和风险因素LP后并发症在内存clinic population.Methods：我们前瞻性地招募了3868例患者（50%的女性，年龄66 +/- 11岁，迷你精神状态检查25 +/- 5）在23个内存诊所。我们使用广义估计方程进行逻辑回归分析，以调查LP后并发症的风险因素，例如典型的腰穿后头痛（PLPH）和背痛。结果：共有1065例患者（31%）报告LP后投诉; 589例患者（17%）报告背痛，649例（19%）头痛，其中296例（9%）报告典型的PLPH。只有少数患者需要医疗干预：11例（0.3%）接受了血液贴片，23例（0.7%）住院治疗。PLPH最重要的危险因素是头痛病史。无创针头和年龄>65岁是预防性的。性别、LP后休息时间或脑脊液量对结果无影响。讨论：并发症的总体风险相对较低。如果考虑到本研究中显示的风险因素，LP可以在记忆诊所安全地进行。(C)2016年阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.