Long‐term Clinical Outcomes of Synchronized Therapy With Plasmapheresis and Intravenous Cyclophosphamide Pulse Therapy in the Treatment of Steroid‐resistant Lupus Nephritis
Long‐term Clinical Outcomes of Synchronized Therapy With Plasmapheresis and Intravenous Cyclophosphamide Pulse Therapy in the Treatment of Steroid‐resistant Lupus Nephritis
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血浆去除术和静脉环磷酰胺脉冲疗法同步治疗类固醇抵抗性狼疮性肾炎的长期临床结果
DOI：
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发表时间：
2008
影响因子：
1.9
通讯作者：
Y. Takasaki
中科院分区：
文献类型：
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作者：
K. Yamaji;Young;H. Tsuda;Y. Takasaki
翻译后摘要：近年来，狼疮性肾炎（LN）患者的重要预后已显着改善，作为类固醇治疗和免疫抑制剂，包括环磷酰胺的管理，但与这些治疗相关的复发病例和并发症是一个问题。 在这项研究中，对38例LN患者的临床特征、缓解率和复发率进行了为期5年的长期回顾性评价，将其分为3组，分别接受血浆置换（PP）、静脉内环磷酰胺冲击治疗（IVCY）或PP和IVCY（同步PP-IVCY）作为类固醇治疗的补充治疗。PP、IVCY和PP-IVCY的完全缓解率分别为5/9（55.6%）、8/16（50.0%）和9/13（69.2%）。PP、IVCY和PP-IVCY的复发率分别为3/9（33.3%）、3/16（18.8%）和1/13（7.7%）。同步PP-IVCY治疗在实现LN完全缓解以及最大限度地降低肾功能受损复发风险方面可能优于PP或IVCY，这是上级治疗。
Abstract: In recent years, the vital prognosis of the patients with lupus nephritis (LN) has improved dramatically as a result of steroid therapy and the administration of immunosuppressants including cyclophosphamide, but recurrent cases and complications associated with these therapies are a concern. In this study, a long‐term retrospective evaluation was performed over a period of five years concerning the clinical characteristics, remission rate and relapse rate by dividing 38 patients with LN into three groups receiving either plasmapheresis (PP), intravenous cyclophosphamide pulse therapy (IVCY), or both PP and IVCY (synchronized PP–IVCY) as the treatments added to steroid therapy. The complete remission rates of PP, IVCY and PP–IVCY were 5/9 (55.6%), 8/16 (50.0%) and 9/13 (69.2%), respectively. The relapsing rates of PP, IVCY and PP–IVCY were 3/9 (33.3%), 3/16 (18.8%) and 1/13 (7.7%), respectively. Synchronized PP–IVCY therapy might be superior to PP or IVCY in achieving complete remission of LN, and in minimizing the risk of relapse of impaired renal function.
影响因子：
158.5
作者：
LEWIS, EJ;HUNSICKER, LG;LACHIN, JM
通讯作者：
LACHIN, JM