Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study
Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study
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DOI：
10.1186/s10194-019-0986-z
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发表时间：
2019-03-25
影响因子：
7.4
通讯作者：
Chung, Chin-Sang
中科院分区：
文献类型：
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作者：
Lee, Mi Ji;Park, Bo-yong;Chung, Chin-Sang
目的采用数据驱动的方法研究慢性偏头痛（CM）患者的全脑静息态功能连接。方法我们前瞻性招募2016年7月至2017年12月在三星医疗中心头痛门诊就诊的18-60岁的阵发性偏头痛（EM）或CM患者。所有患者均使用相同的扫描仪接受3T MRI检查。如果患者在功能性 MRI 采集当天和第 1 天没有出现偏头痛，则被认为是发作间期。使用组独立成分分析（ICA），使用加权无向网络模型进行连通性分析。使用 5000 个排列检验并用错误发现率 (FDR) 校正来评估组间程度中心性 (DC) 值的差异。 结果 共有 62 名患者（44 名 EM 和 18 CM）纳入本研究。在确定的七个功能上可解释的空间独立成分 (IC) 中，只有一个 IC（被解释为疼痛矩阵）在 DC 中显示出显着的组间差异（CM>EM，p=0.046）。在调整年龄、性别、先兆偏头痛 (MWA)、异常性疼痛、抑郁和焦虑后，这种相关性仍然显着 (p=0.038)。疼痛矩阵与下丘脑 (p=0.040, EM>CM) 和中缝背核 (p=0.039, CM>EM) 存在功能相关性，且 EM 和 CM 的强度水平不同。 结论 p id=Par4 CM 患者的疼痛矩阵连接性强于 EM 患者。疼痛网络的功能改变可能在偏头痛慢性化中发挥作用。
ObjectiveTo investigate the whole-brain resting-state functional connectivity in patients with chronic migraine (CM) using a data-driven method.MethodsWe prospectively recruited patients with either episodic migraine (EM) or CM aged 18-60years who visited the headache clinic of the Samsung Medical Center from July 2016 to December 2017. All patients underwent 3T MRI using an identical scanner. Patients were considered interictal if they did not have a migraine headache at the day and1days of functional MRI acquisition. Using the group-independent component analysis (ICA), connectivity analysis with a weighted and undirected network model was performed. The between-group differences in degree centrality (DC) values were assessed using 5000 permutation tests corrected with false discovery rate (FDR).ResultsA total of 62 patients (44 EM and 18 CM) were enrolled in this study. Among the seven functionally interpretable spatially independent components (ICs) identified, only one IC, interpreted as the pain matrix, showed a significant between-group difference in DC (CM>EM, p=0.046). This association remained significant after adjustment for age, sex, migraine with aura (MWA), allodynia, depression, and anxiety (p=0.038). The pain matrix was functionally correlated with the hypothalamus (p=0.040, EM>CM) and dorsal raphe nucleus (p=0.039, CM>EM) with different levels of strength in EM and CM.Conclusion p id=Par4 CM patients have a stronger connectivity in the pain matrix than do EM patients. Functional alteration of the pain network might play a role in migraine chronification.