The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential.
The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential.
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DOI：
10.3389/fimmu.2023.1158083
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
白细胞衍生趋化因子-2，又名CHM-II，最初被认为是一种介导中性粒细胞迁移的趋化因子，是一种多功能的分泌因子，参与多种生理和病理过程。不同脊椎动物间LECT2的高度序列相似性为利用比较生物学手段研究其功能提供了可能。LECT2通过与不同细胞类型的CD209a、Tie1、Met等细胞表面受体结合，参与多种免疫过程和免疫相关疾病。此外，LECT2的错误折叠导致几个重要组织(肾、肝和肺等)的淀粉样变性。通过诱导不溶纤维的形成。然而，由于功能和信号的异质性，LECT2在不同组织中介导的不同免疫致病状态的机制仍未完全阐明。本文就LECT2的结构、“双刃剑”功能、在免疫疾病中广泛的信号转导途径以及在临床前或临床试验的治疗干预中的潜在应用作一综述。本文就LECT2与免疫疾病的关系提供了一个综合的观点，旨在促进针对LECT2的药物或探针的开发，用于免疫相关疾病的治疗。
Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types. In addition, the misfolding LECT2 leads to the amyloidosis of several crucial tissues (kidney, liver, and lung, etc.) by inducing the formation of insoluble fibrils. However, the mechanisms of LECT2-mediated diverse immune pathogenic conditions in various tissues remain to be fully elucidated due to the functional and signaling heterogeneity. Here, we provide a comprehensive summary of the structure, the “double-edged sword” function, and the extensive signaling pathways of LECT2 in immune diseases, as well as the potential applications of LECT2 in therapeutic interventions in preclinical or clinical trials. This review provides an integrated perspective on the current understanding of how LECT2 is associated with immune diseases, with the aim of facilitating the development of drugs or probes against LECT2 for the theranostics of immune-related diseases.
影响因子：
5
作者：
Jeronimo, S. M. B.;Holst, A. K. B.;Jamieson, S. E.;Francis, R.;Martins, D. R. A.;Bezerra, F. L.;Ettinger, N. A.;Nascimento, E. T.;Monteiro, G. R.;Lacerda, H. G.;Miller, E. N.;Cordell, H. J.;Duggal, P.;Beaty, T. H.;Blackwell, J. M.;Wilson, M. E.
通讯作者：
Wilson, M. E.