Hemostatic laboratory derangements in COVID-19 with a focus on platelet count
Hemostatic laboratory derangements in COVID-19 with a focus on platelet count
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DOI：
10.1080/09537104.2020.1768523
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发表时间：
2020-05-29
期刊：
影响因子：
3.3
通讯作者：
Othman, Maha
中科院分区：
文献类型：
--
作者：
Amgalan, Ariunzaya;Othman, Maha
严重急性呼吸系统综合征冠状病毒2 （SARS-CoV-2）是2019年冠状病毒病（COVID-19）的罪魁祸首，该疾病从中国武汉的疫情迅速演变为一场大流行，导致全球数百万人感染，数十万人死亡。各种凝血功能病变已被报道与COVID-19相关，包括弥散性血管内凝血（DIC）、脓毒症诱导的凝血功能病变（SIC）、局部微血栓、静脉血栓栓塞（VTE）、动脉血栓并发症和血栓炎症。关于COVID-19的血液学和止血紊乱的出版物过多，数据相互矛盾，一些数据表明这与疾病进展、严重程度和/或死亡率有关。越来越多的证据表明，有可能有用的临床生物标志物可以预测COVID-19的进展和疾病结局。其中，血小板减少症与COVID-19严重程度或死亡率之间存在联系。在本意见报告中，我们研究了已发表的关于COVID-19和相关的SARS-CoV-2诱导炎症的血液学和止血实验室紊乱的证据，重点讨论了血小板计数改变。我们探讨血小板减少症是否可能是一种潜在的疾病生物标志物，并为这方面的未来研究提供建议。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over hundreds of thousands of mortalities worldwide. Various coagulopathies have been reported in association with COVID-19, including disseminated intravascular coagulation (DIC), sepsis-induced coagulopathy (SIC), local microthrombi, venous thromboembolism (VTE), arterial thrombotic complications, and thrombo-inflammation. There is a plethora of publications and conflicting data on hematological and hemostatic derangements in COVID-19 with some data suggesting the link to disease progress, severity and/or mortality. There is also growing evidence of potentially useful clinical biomarkers to predict COVID-19 progression and disease outcomes. Of those, a link between thrombocytopenia and COVID-19 severity or mortality was suggested. In this opinion report, we examine the published evidence of hematological and hemostatic laboratory derangements in COVID-19 and the interrelated SARS-CoV-2 induced inflammation, with a focussed discussion on platelet count alterations. We explore whether thrombocytopenia could be a potential disease biomarker and we provide recommendations for future studies in this regard.