Gadd45 proteins: relevance to aging, longevity and age-related pathologies.
Gadd45 proteins: relevance to aging, longevity and age-related pathologies.
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GADD45蛋白质：与衰老，寿命和与年龄相关的病理相关。
DOI：
10.1016/j.arr.2011.09.003
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发表时间：
2012-01
影响因子：
13.1
通讯作者：
Fraifeld, Vadim E.
中科院分区：
文献类型：
--
作者：
Moskalev, Alexey A.;Smit-McBride, Zeljka;Shaposhnikov, Mikhail V.;Plyusnina, Ekaterina N.;Zhavoronkov, Alex;Budovsky, Arie;Tacutu, Robi;Fraifeld, Vadim E.
鉴于Gadd45蛋白在关键细胞过程中的重要作用，人们对其进行了深入研究。事实上，Gadd45蛋白站在细胞命运的十字路口，通过控制细胞（DNA）修复、消除（凋亡）或防止潜在危险细胞（细胞周期阻滞、细胞衰老）的扩张和维持干细胞库之间的平衡。然而，到目前为止，生物老年学方面还没有得到足够的重视。在这里，我们分析了Gadd45成员参与衰老、长寿和年龄相关疾病的途径和作用模式。由于其多效性，Gadd45成员诱导性的降低可能会产生深远的影响，包括基因组不稳定、DNA损伤积累和细胞稳态紊乱——所有这些最终都可能导致衰老过程和年龄相关疾病（促进肿瘤发生、免疫紊乱、胰岛素抵抗和应激反应性降低）。最近，dGadd45基因被确定为果蝇的寿命调节因子。虽然需要进一步的大规模研究，但越来越清楚的是，gadd45与衰老、年龄相关疾病（ARDs）和寿命控制高度相关，这表明它们是ARDs和促进长寿干预的潜在治疗靶点。
The Gadd45 proteins have been intensively studied, in view of their important role in key cellular processes. Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by controlling the balance between cell (DNA) repair, eliminating (apoptosis) or preventing the expansion of potentially dangerous cells (cell cycle arrest, cellular senescence), and maintaining the stem cell pool. However, the biogerontological aspects have not thus far received sufficient attention. Here we analyzed the pathways and modes of action by which Gadd45 members are involved in aging, longevity and age-related diseases. Because of their pleiotropic action, a decreased inducibility of Gadd45 members may have far-reaching consequences including genome instability, accumulation of DNA damage, and disorders in cellular homeostasis – all of which may eventually contribute to the aging process and age-related disorders (promotion of tumorigenesis, immune disorders, insulin resistance and reduced responsiveness to stress). Most recently, the dGadd45 gene has been identified as a longevity regulator in Drosophila. Although further wide-scale research is warranted, it is becoming increasingly clear that Gadd45s are highly relevant to aging, age-related diseases (ARDs) and to the control of life span, suggesting them as potential therapeutic targets in ARDs and pro-longevity interventions.
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影响因子：
8
作者：
Amundson, SA;Zhan, Q;Fornace, AJ
通讯作者：
Fornace, AJ
影响因子：
4.3
作者：
Ceryak, S;Zingariello, C;Patierno, SR
通讯作者：
Patierno, SR
影响因子：
64.8
作者：
Barreto, Guillermo;Schaefer, Andrea;Niehrs, Christof
通讯作者：
Niehrs, Christof
DOI：
10.1073/pnas.97.8.4291
发表时间：
2000-04-11
影响因子：
11.1
作者：
Chang, BD;Watanabe, K;Roninson, IB
通讯作者：
Roninson, IB
影响因子：
4.8
作者：
Azam, N;Vairapandi, M;Liebermann, DA
通讯作者：
Liebermann, DA