Brown and Beige Fat: Physiological Roles beyond Heat Generation.
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
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DOI：
10.1016/j.cmet.2015.09.007
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发表时间：
2015-10-06
期刊：
影响因子：
29
通讯作者：
Seale P
中科院分区：
文献类型：
--
作者：
Kajimura S;Spiegelman BM;Seale P
由于棕色脂肪组织（BAT）通过UCP 1消耗能量，BAT作为肥胖和代谢疾病（包括2型糖尿病）的治疗干预措施已引起关注。随着我们更好地了解经典棕色和米色脂肪细胞的生理作用，越来越清楚的是，BAT不仅仅是一个发热器官。响应于各种外部/内部线索的米色脂肪量增加与葡萄糖和脂质稳态的显著改善相关，这可能不完全由UCP 1介导。我们的目的是讨论最近的见解，关于棕色和米色脂肪细胞的发育谱系，分子调控和新的功能。
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.