Monosynaptic facilitation mediated by group Ia afferents from deltoid to biceps brachii motoneurons in humans

Monosynaptic facilitation mediated by group Ia afferents from deltoid to biceps brachii motoneurons in humans
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人类从三角肌到肱二头肌运动神经元的 Ia 组传入神经介导的单突触促进

DOI:
10.1007/s00221-022-06332-8
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发表时间:
2022
影响因子:
2
通讯作者:
Naito Akira
Naito Akira
中科院分区:
医学4区
文献类型:
--
作者:
Yoshimoto Takuya;Nito Mitsuhiro;Hashizume Wataru;Miyasaka Takuji;Shindo Masaomi;Naito Akira

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研究了来自三角肌前部 (DA)、中部 (DM) 和后部 (DP) 的低阈值传入对人类肱二头肌 (BB) 运动神经元兴奋性的影响。我们分别使用刺激后时间直方图 (PSTH) 和肌电图平均 (EMG-A) 方法在 11 名健康人类受试者中评估了对个体运动单位和运动神经元池的影响。将电调节刺激传递至支配DA(DA神经)、DM(DM神经)和DP(DP神经)的腋神经分支,其强度低于运动阈值。在 PSTH 研究中,对 DA、DM 和 DP 神经的刺激分别在 26/40 (65%)、28/47 (59%) 和 0/32 (0%) 的 BB 运动单位中产生显着的峰值(促进)。由于 DA 和 DM 神经促进的中枢潜伏期分别比 BB 的同名单突触 Ia 促进长 0.1±0.3 和 0.1±0.2 ms(平均值±S.D.),因此该促进与单突触路径兼容。在 EMG-A 研究中,对 DA 和 DM 神经的刺激对所有受试者的 BB 运动神经元池产生了显着的峰值(促进),而对 DP 神经的刺激对 BB 没有影响。振动刺激会减弱促进作用,去除振动后抑制会持续 30-40 分钟。因此,Ia 组传入神经应负责促进。这些发现表明人类中存在由从 DA 和 DM 神经到 BB 运动神经元的 Ia 组传入神经介导的单突触促进。
Effects of low-threshold afferents from the anterior (DA), middle (DM) and posterior parts of the deltoid (DP) on the excitability of biceps brachii (BB) motoneurons in humans were studied. We evaluated the effects on individual motor units and motoneuron pool using a post-stimulus time-histogram (PSTH) and an electromyogram-averaging (EMG-A) methods, respectively, in 11 healthy human subjects. Electrical conditioning stimulation was delivered to the axillary nerve branch innervating DA (DA nerve), DM (DM nerve) and DP (DP nerve) with the intensity below the motor threshold. In the PSTH study, stimulation to the DA, DM and DP nerves produced a significant peak (facilitation) in 26/40 (65%), 28/47 (59%) and 0/32 (0%) of BB motor units, respectively. Since the central latency of the facilitation from the DA and DM nerves was 0.1 ± 0.3 and 0.1 ± 0.2 ms (mean ± S.D.) longer than that of the homonymous monosynaptic Ia facilitation of BB, respectively, the facilitation thus being compatible with monosynaptic path. In the EMG-A study, stimulation to the DA and DM nerves produced a significant peak (facilitation) for the BB motoneuron pool in all the subjects, whereas stimulation to the DP nerve produced no effect on BB. The facilitation diminished by vibration stimulation, and the suppression lasted for 30–40 min after removal of the vibration. Therefore, group Ia afferents should be responsible for the facilitation. These findings suggest that monosynaptic facilitation mediated by group Ia afferents from the DA and DM nerves to BB motoneurons exists in humans.
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