Power(2): the power of yeast genetics applied to the powerhouse of the cell.
Power(2): the power of yeast genetics applied to the powerhouse of the cell.
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DOI：
10.1016/j.tem.2014.12.002
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Hughes AL
中科院分区：
文献类型：
--
作者：
Rutter J;Hughes AL
出芽酵母酿酒酵母作为一种出色的模式生物，在生物学众多开创性发现中发挥了作用。这种范例延伸到了线粒体，它是细胞代谢的核心枢纽，在酵母中的研究有助于重振该领域，并开启了线粒体生物学令人兴奋的新时代。在此，我们讨论一些近期的例子，其中酵母研究为我们理解进化上保守的线粒体过程和功能奠定了基础；从参与氧化磷酸化复合物组装的关键因子和途径，到代谢物运输、脂质代谢以及细胞器间通讯。我们还强调了酵母线粒体生物学的新领域，这些领域可能在未来几年有助于我们理解疾病的线粒体病因。
The budding yeast Saccharomyces cerevisiae has served as a remarkable model organism for numerous seminal discoveries in biology. This paradigm extends to the mitochondria, a central hub for cellular metabolism, where studies in yeast have helped reinvigorate the field and launch an exciting new era in mitochondrial biology. Here, we discuss few recent examples in which yeast research has laid a foundation for our understanding of evolutionarily conserved mitochondrial processes and functions; from the key factors and pathways involved in the assembly of the OXPHOS complexes, to metabolite transport, lipid metabolism, and interorganelle communication. We also highlight new areas of yeast mitochondrial biology that will likely aid in our understanding of mitochondrial etiology of disease in the years to come.