THE PHARMACOKINETIC PROFILES OF OCHRATOXIN-A IN PIGS, RABBITS AND CHICKENS
THE PHARMACOKINETIC PROFILES OF OCHRATOXIN-A IN PIGS, RABBITS AND CHICKENS
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DOI：
10.1016/0015-6264(81)90528-9
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
CHARPENTEAU, JL
中科院分区：
文献类型：
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作者：
GALTIER, P;ALVINERIE, M;CHARPENTEAU, JL
分别以0.5、2和2 mg/kg体重的剂量水平对猪、兔和鸡进行口服或静脉注射赭曲霉毒素A。在处理后长达120小时内测量血浆中真菌毒素的浓度。药代动力学参数显示二室开放模型。经口给药后，赭曲霉毒素A在猪、兔和鸡中的生物半衰期分别为88.8、8.2和4.1 h，吸收剂量分别为给药剂量的65.7、55.6和40.0%。赭曲霉毒素A在猪体内持续存在。计算的兔和鸡的表观分布容积较大，表明毒素分布较广。生理过程，如血清白蛋白结合，消化流率或生物转化途径被认为是赭曲霉毒素A的药代动力学观察到的物种差异。
Ochratoxin A was administered orally or by i.v. injection to pigs, rabbits and chickens at dose levels of 0.5, 2 and 2 mg/kg body wt, respectively. Concentrations of the mycotoxin in the plasma were measured for up to 120 h following treatment. Pharmacokinetic parameters indicated a 2 compartment open model. Following oral administration, the biological half-life of ochratoxin A was 88.8, 8.2 and 4.1 h in pigs, rabbits and chickens, respectively, and 65.7, 55.6 and 40.0%, respectively, of the administered dose was absorbed. Ochratoxin A persisted in the body of the pig. The large apparent volumes of distribution calculated for the rabbit and chicken indicated a wide distribution of the toxin. Physiological processes such as serum albumin binding, digestive flow rate or biotransformation pathways were suggested for the observed species differences in the pharmacokinetics of ochratoxin A.