Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis
Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis
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DOI：
10.4193/rhin.08.109
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发表时间：
2009-09-01
期刊：
影响因子：
7.2
通讯作者：
Ikeda, Katsuhisa
中科院分区：
文献类型：
--
作者：
Saitoh, Tatsuya;Kusunoki, Takeshi;Ikeda, Katsuhisa
背景：慢性鼻窦炎（CRS）伴鼻息肉以嗜酸性粒细胞浸润为特征。本研究假设鼻息肉患者鼻黏膜重塑过程中的病理聚集与嗜酸性粒细胞浸润有关。目的：探讨嗜酸性粒细胞在CRS鼻息肉患者鼻息肉中的发病作用，探讨鼻息肉患者鼻黏膜上皮损伤或基底膜（BM）增厚与嗜酸性粒细胞浸润的关系。计数鼻腔鼻窦上皮及上皮下浸润的嗜酸性粒细胞数。上皮损伤的分期允许定量上皮loss.Results：上皮损伤和BM厚度在CRS，这是与浸润的嗜酸性粒细胞的数量，显着大于对照组。哮喘组和非哮喘组之间的参数均无显著差异。结论：嗜酸性粒细胞同时浸润鼻息肉的上皮层和上皮层，在鼻息肉的黏膜重塑过程中起重要作用。
Background: Chronic rhinosinusitis (CRS) with nasal polyps is characterized by eosinophilic infiltration. This study hypothesized that the aggregation of the mucosal pathology during remodeling is related to infiltrating eosinophils in patients with such nasal polyps.Object: To clarify the pathogenetic role of eosinophils ill patients with CRS with nasal polyps, this study investigated the relationship between epithelial damage or basement membrane (BM) thickening and the epithelial infiltration of eosinophils in these nasal polyps.Methods: The number of eosinophils that infiltrated into the epithelial and subepithelial layers of sinonasal tissues was counted. The staging of epithelial damage allowed the quantification of epithelial loss.Results: Both epithelial damage and BM thickness in CRS, which were correlated with the number of infiltrated eosinophils, were significantly greater than in the control group. Neither parameter showed significant differences between the asthma and non-asthma groups. There was a significantly correlation in the eosinophilic infiltration between the subepithelial and epithelial layers.Conclusion: It is suggested that eosinophils that infiltrate into both the epithelial and subepithelial layers play a part in the process of mucosal remodeling of CRS with nasal polyps.