A model for aortic growth based on fluid shear and fiber stresses
A model for aortic growth based on fluid shear and fiber stresses
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DOI：
10.1115/1.2798001
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发表时间：
1998-06-01
影响因子：
1.7
通讯作者：
Taber, LA
中科院分区：
文献类型：
--
作者：
Taber, LA
使用理论模型研究了主动脉应力调节生长。该模型是由代表内膜/中膜和外膜的两个伪弹性正交各向异性层组成的厚壁管。假设这两层都遵循生长规律，其中生长拉伸比的时间变化率线性依赖于局部平滑肌纤维应力和由于血流在内皮上引起的剪切应力。利用修正的有限弹性理论，包括体积增长，我们计算了在发育过程中和突发性高血压发作后应力、几何形状和开口角（残余应变）的时间变化。对于生长规律中适当的系数值，该模型得出的结果与已发表的大鼠主动脉整体和局部生长数据基本一致。
Stress-modulated growth in the aorta is studied using a theoretical model. The model is a thick-walled tube composed of two pseudoelastic, orthotropic layers representing the intima/media and the adventitia. both layers are assumed to follow a growth law in which the time rates of change of the growth stretch ratios depend linearly on the local smooth muscle fiber stress and on the shear stress due to blood flow on the endothelium. Using finite elasticity theory modified to include volumetric growth, we computed temporal changes in stress, geometry, and opening angle (residual strain) during development and following the onset of sudden hypertension. for appropriate values of the coefficients in the growth law, the model yields results in reasonable agreement with published data for global and local growth of the rat aorta.