Day/Night rhythm of hemostatic factors in obstructive sleep apnea.
Day/Night rhythm of hemostatic factors in obstructive sleep apnea.
复制标题
阻塞性睡眠呼吸暂停中止血因素的昼夜节律。
DOI：
10.1093/sleep/33.3.371
复制
发表时间：
2010
期刊：
影响因子：
5.6
通讯作者：
Dimsdale,JoelE
中科院分区：
文献类型：
--
作者：
vonKänel,Roland;Natarajan,Loki;Ancoli-Israel,Sonia;Mills,PaulJ;Loredo,JoséS;Dimsdale,JoelE
Study ObjectivesTo investigate the hypothesis that day/night patterns of prothrombotic activity differ between patients with obstructive sleep apnea (OSA) and individuals with no OSA.DesignProthrombotic markers' day/night rhythms recorded over one 24-h period.SettingGeneral clinical research center.Patients38 untreated OSA patients as verified by polysomnography (apnea-hypopnea index >10/h sleep) and 22 non-OSA controls.Measurements and ResultsBlood samples were collected every 2 h to measure plasma levels of fibrinolysis-inhibiting plasminogen activator inhibitor (PAI)-1 and the primary fibrin degradation product D-dimer. Day/night variation in hemostasis factors was examined using a cosinor analysis. Mesor (mean) PAI-1 over the 24-h period was higher (P = 0.015), and mesor of D-dimer was lower (P = 0.001 ) in patients with OSA than in the non-OSA controls. These group differences stayed significant when controlling for age and gender. After further adjustment for body mass index, mean arterial pressure, and smoking, the relationship between OSA and PAI-1 became non-significant, but the relationship between OSA and D-dimer continued to be significant (P = 0.006). In the fully adjusted analysis, the amplitude (peak) for D-dimer was lower in OSA patients than in non-OSA controls (P = 0.048). The acrophase (time of the peak) for PAI-1 and D-dimer did not significantly differ between groups.ConclusionsThe relatively higher average level of PAI-1 and lower average level of D-dimer across the 24-h in OSA patients might reflect decreased fibrinolytic capacity and fibrin degradation, respectively. The findings provide some evidence for a prothrombotic state in OSA, but were only partially independent of metabolic variables.
登录
查看更多内容
影响因子：
5
作者：
C. Zamarrón;J. Ricoy;A. Riveiro;F. Gudé
通讯作者：
C. Zamarrón;J. Ricoy;A. Riveiro;F. Gudé
第二版
DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
Fujita J. Springer;Berlin;Schwab;M.(ed.)
通讯作者：
M.(ed.)
通过血清 D-二聚体测试评估总体纤溶能力。
影响因子：
7.5
作者：
I. Seljeflot;J. Eritsland;P. Andersen;H. Arnesen
通讯作者：
H. Arnesen
影响因子：
37.8
作者：
RIDKER, PM;HENNEKENS, CH;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
DOI：
10.1016/s0002-9149(03)00428-4
发表时间：
2003-06
期刊：
The American journal of cardiology
影响因子：
--
作者：
A. Selwyn
通讯作者：
A. Selwyn