DMEAS: DNA methylation entropy analysis software
DMEAS: DNA methylation entropy analysis software
复制标题
DMEAS：DNA甲基化熵分析软件
DOI：
10.1093/bioinformatics/btt332
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发表时间：
2013-08-15
期刊：
影响因子：
5.8
通讯作者：
Xie, Hehuang
中科院分区：
文献类型：
--
作者：
He, Jianlin;Sun, Xinxi;Xie, Hehuang
总结：DMEAS是第一个用户友好的工具，专门用于分析DNA甲基化模式的分布，以量化表观遗传异质性。它支持基因座特异性和全基因组亚硫酸氢盐测序数据的分析。DMEAS逐步扫描亚硫酸氢盐测序读数的映射结果，以提取连续CpG二核苷酸的DNA甲基化模式。它确定DNA甲基化水平并计算基因组片段的甲基化熵，以定量评估细胞群体中观察到的DNA甲基化变异。可用性和实施：DMEAS程序、用户指南和所有测试数据可从www.example.com免费获得davidxie@vt.edu人：http://sourceforge.net/projects/dmeas/files/补充信息：补充数据可在生物信息学在线获得。
Summary: DMEAS is the first user-friendly tool dedicated to analyze the distribution of DNA methylation patterns for the quantification of epigenetic heterogeneity. It supports the analysis of both locus-specific and genome-wide bisulfite sequencing data. DMEAS progressively scans the mapping results of bisulfite sequencing reads to extract DNA methylation patterns for contiguous CpG dinucleotides. It determines the DNA methylation level and calculates methylation entropy for genomic segments to enable the quantitative assessment of DNA methylation variations observed in cell populations. Availability and implementation: DMEAS program, user guide and all the testing data are freely available from http://sourceforge.net/projects/dmeas/files/ Contact: davidxie@vt.edu Supplementary Information: Supplementary data are available at Bioinformatics online.