Contractile and biochemical properties of diaphragm: effects of exercise training and fatigue.
Contractile and biochemical properties of diaphragm: effects of exercise training and fatigue.
复制标题
膈肌的收缩和生化特性：运动训练和疲劳的影响。
DOI：
10.1152/jappl.1986.60.5.1752
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Fitts,RH
中科院分区：
文献类型：
--
作者：
Metzger,JM;Fitts,RH
检查高强度训练（6 X 4.5 分钟，40 m/min，15% 等级，训练间休息 2.5 分钟，5 天/周，持续 6 周）对大鼠膈肌收缩、生化和疲劳特性的影响。锻炼计划使比目鱼肌 (SOL)（27.2 +/- 1.5 与 46.7 +/- 2.4；平均值 +/- SE）、深股外侧肌 (DVL)（40.8 +/- 2.6 与 58.3 +/- 2.8）和浅股外侧肌的线粒体标记酶柠檬酸合酶 (mumol X g-1 X min-1) 显着升高 (SVL)（8.5 +/- 0.6 与 11.4 +/- 0.7）。在脚侧 (CRU)（45.9 +/- 2.0 与 44.0 +/- 2.3）或腹侧肋 (VEN)（41.5 +/- 2.0 与 45.8 +/- 2.6）膈肌区域没有观察到显着差异。磷酸果糖激酶（糖酵解限速酶）的 SOL（19.0 +/- 0.8 vs. 23.3 +/- 1.3 mumol X g-1 X min-1）和 DVL（69.3 +/- 6.0 vs. 86.6 +/- 5.0）显着增加，但 SVL（98.6 +/- 5.7 vs. 98.6 +/- 5.7 vs. 106.1+/- 9.0）、CRU（54.4 +/- 2.8 与 53.8 +/- 1.5）或 VEN（44.7 +/- 2.4 与 46.4 +/- 1.4）训练后。训练后，除了抽搐张力下降率增加外，膈肌收缩特性保持不变。休息时训练过的膈肌的糖原值显着较高（6.54 +/- 0.39 vs. 4.86 +/- 0.41 mg/g）以及疲劳刺激 1、5 和 10 分钟期间。在疲劳期间，训练组与对照组的力量、力量上升速率、力量下降速率、肌肉乳酸、ATP 或磷酸肌酸没有观察到差异。（摘要截断为 250 字）
The effect of high-intensity trained (6 X 4.5 min at 40 m/min, 15% grade, 2.5-min rest between bouts, 5 days/wk, for 6 wk) on contractile, biochemical, and fatigue properties of the rat diaphragm were examined. The exercise program produced significant elevations in the mitochondrial marker enzyme citrate synthase (mumol X g-1 X min-1) in the soleus (SOL) (27.2 +/- 1.5 vs. 46.7 +/- 2.4; mean +/- SE), deep vastus lateralis (DVL) (40.8 +/- 2.6 vs. 58.3 +/- 2.8), and superficial vastus lateralis (SVL) (8.5 +/- 0.6 vs. 11.4 +/- 0.7). No significant differences were observed in the crural (CRU) (45.9 +/- 2.0 vs. 44.0 +/- 2.3) or ventral costal (VEN) (41.5 +/- 2.0 vs. 45.8 +/- 2.6) diaphragmatic regions. Phosphofructokinase, the rate-limiting enzyme of glycolysis, significantly increased in the SOL (19.0 +/- 0.8 vs. 23.3 +/- 1.3 mumol X g-1 X min-1) and DVL (69.3 +/- 6.0 vs. 86.6 +/- 5.0), but no alterations were seen in the SVL (98.6 +/- 5.7 vs. 106.1 +/- 9.0), CRU (54.4 +/- 2.8 vs. 53.8 +/- 1.5), or VEN (44.7 +/- 2.4 vs. 46.4 +/- 1.4) posttraining. Diaphragm contractile properties, with the exception of an increased rate of fall in twitch tension, remained unchanged after training. Glycogen values were significantly higher in trained diaphragms at rest (6.54 +/- 0.39 vs. 4.86 +/- 0.41 mg/g) and during 1, 5, and 10 min of fatiguing stimulation. During fatigue no differences were observed in force, rate of rise in force, rate of fall in force, muscle lactate, ATP, or creatine phosphate in trained vs. control.(ABSTRACT TRUNCATED AT 250 WORDS)