Associations Between Metabolic Syndrome and Mortality From Cardiovascular Disease in Japanese General Population, Findings on Overweight and Non-Overweight Individuals - Ibaraki Prefectural Health Study
Associations Between Metabolic Syndrome and Mortality From Cardiovascular Disease in Japanese General Population, Findings on Overweight and Non-Overweight Individuals - Ibaraki Prefectural Health Study
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DOI：
10.1253/circj.cj-08-0442
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Ota, Hitoshi
中科院分区：
文献类型：
--
作者：
Irie, Fujiko;Iso, Hiroyasu;Ota, Hitoshi
背景：超重作为代谢综合征(METS)的一部分，对心血管疾病(CVD)死亡率的影响进行了调查，并与两种不同定义的METS的预测价值进行了比较。方法和结果：对30,774名日本男性和60,383名女性进行了为期12年的前瞻性研究，年龄在40-79岁。总心血管病死亡率的多变量危险比(HR；95%可信区间)：男性为1.83(1.41-2.38)，女性为1.90(1.45-2.49)；非超重者为1.75(1.38-2.24)，非超重者为1.97(1.52-2.55)。后一组的超额死亡比例是前一组的1.5倍。按美国心脏协会/美国国家心肺血液研究所的修订标准计算，男性冠心病和总心血管病死率男性分别为1.62(1.31~2.00)和1.23(1.09~1.39)，女性分别为1.32(1.05~1.65)和1.12(1.00~1.25)。结论：有代谢危险因素的非超重人群和有代谢危险因素的超重人群应作为降低一般人群心血管负担的目标人群。(保监会J 2009；73：1635-1642)
Background: The impact of being overweight, as a component of the metabolic syndrome (MetS), for cardiovascular disease (CVD) mortality was investigated and compared with the predictive value of MetS by 2 different definitions.Methods and Results: A 12-year prospective study of 30,774 Japanese men and 60,383 women aged 40-79 years was conducted. The multivariate hazard ratio (HR; 95% confidence interval) of total CVD mortality for overweight subjects with >= 2 additional risk factors with reference to subjects with 0 of 4 MetS components was 1.83 (1.41-2.38) for men and 1.90 (1.45-2.49) for women, and for non-overweight subjects with >= 2 additional risk factors, 1.75 (1.38-2.24) and 1.97 (1.52-2.55), respectively. The proportion of excess CVD deaths in the latter group was 1.5-fold higher than that in the former group. Multivariate HRs of coronary heart disease and total CVD mortality for MetS by the modified criteria of the American Heart Association/National Heart, Lung, and Blood Institute were 1.62 (1.31-2.00) and 1.23 (1.09-1.39), respectively, for men and 1.32 (1.05-1.65) and 1.12 (1.00-1.25), respectively, for women. The respective HRs for MetS by the International Diabetic Federation definition did not reach statistical significance, except for coronary heart disease in men.Conclusions: Non-overweight individuals with metabolic risk factors, as well as overweight individuals with such factors, should be targeted to reduce the CVD burden in the general Population. (Circ J 2009; 73: 1635-1642)