The correlation between hepatic lipase gene-763A/G polymorphism and combined hyperlipidemia
The correlation between hepatic lipase gene-763A/G polymorphism and combined hyperlipidemia
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发表时间：
2010
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通讯作者：
Yin Yayun
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作者：
Yin Yayun
目的探讨混合型高脂血症（CHL）与肝脂酶（HL）基因启动子763 A/G多态性的关系应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对219例正常人和218例慢性乙型肝炎（CHL）患者进行检测，结果在HL-763 A/G基因多态性研究组中，AA、AG、GG基因型频率分别为0.3155，0.4936，0.1908，CHL组中除年龄、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A-Ⅰ（apo A-Ⅰ）、AA型低密度脂蛋白胆固醇（LDL-C）、载脂蛋白B（apo B）和GG型载脂蛋白A-Ⅰ水平外，其他指标与对照组基因型间差异有统计学意义GG型患者的年龄明显低于AA型患者（P0.05 AA型患者载脂蛋白A-Ⅰ水平显著高于AA型患者（P0.05而载脂蛋白A-Ⅰ和载脂蛋白A-Ⅰ/载脂蛋白B比值明显高于AG型（P < 0.05 CHL雄性组除AA型HDL-C、GG型HDL-C和apoA-Ⅰ水平外，其余血脂水平均高于对照组女性CHL组除HDL-C、apoA-Ⅰ、non-high density lipoprotein cholesterol GG型的血清HDL-C、apo B水平及其他血脂水平均高于对照组结论HL基因启动子763 A/G多态性与CHL的发生有关，可能影响血脂代谢。
Objective To explore the correlation between combined hyperlipidemia(CHL) and hepatic lipase(HL) gene promoter 763A/G polymorphism.Methods HL gene promoter 763A/G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique in 219 controls and 218 cases of patients with CHL,and its influence on blood lipid levels was analyzed.Results In the total study group of HL-763A/G polymorphism,the frequencies of the genotype AA,AG and GG were 0.315 5,0.493 6,0.190 8,and the frequencies of allele A and G were 0.562 3 and 0.437 7.In the CHL group,except age,high-density lipoprotein cholesterol(HDL-C),apolipoprotein A-Ⅰ(apo A-Ⅰ),AA type low-density lipoprotein cholesterol(LDL-C),apolipoprotein B(apo B) and GG type of apo A-Ⅰ levels,other indicators had statistical significance with the control group between genotypes(P0.05).The age in GG type was significantly lower than that in AA type(P0.05),and apo A-Ⅰ levels were significantly higher than those of AA type(P0.05),while the levels of apo A-Ⅰ and apo A-Ⅰ/apo B were significantly higher than those of AG type(P0.05).In the CHL male group,except HDL-C of AA type,HDL-C of GG type and apo A-Ⅰ levels,the levels of other lipids were higher than those in the control male group(P0.05).In the CHL female group,except HDL-C,apo A-Ⅰ,non-high-density lipoprotein cholesterol(nonHDL-C),apo B levels of GG type,the other levels of lipids were higher than those in the control female group(P0.05).In the CHL female group,the levels of apo A-Ⅰ of GG type were significantly higher than those of the AA type(P0.05).Conclusions HL promoter 763A/G polymorphism has the relationship with the occurrence of CHL,and may influence plasma lipid metabolism.