Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat
Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat
复制标题
DOI：
10.1002/adhm.201601355
复制
发表时间：
2017-03-08
影响因子：
10
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Choi, Jungil;Kang, Daeshik;Rogers, John A.
从皮肤目标区域释放的微升汗液的时间顺序捕获系统提供了在感兴趣的整个时期内分析电解质平衡和生物标记物浓度的时间变化的可能性。目前依赖于贴在皮肤上的吸收垫的方法不能提供定量跟踪所需的汗液捕获所需的易用性；新兴类别的电子可穿戴汗液分析系统不能直接管理汗液诱导的液体流动以进行样本分离。在这里，一个薄的，柔软的，像皮肤一样的微流控平台被引入，它结合到皮肤上，允许在一组相互连接的微库中收集和存储汗液。汗腺产生的压力通过微通道网络流动，微通道结合了毛细管爆破阀，设计成在不同的压力下打开，目的是以顺序的方式被动地引导汗液通过系统。一种代表性的设备从大约5个腺体的0.03厘米(2)皮肤区域中收集每0.8分钟出汗的1.8亩L汗液到一组独立的微贮器中，对应于每个腺体的出汗率为0.6亩L分钟(-1)。人体研究展示了在乳酸盐、钠和钾浓度及其时间变化的准确化学分析中的应用。
Systems for time sequential capture of microliter volumes of sweat released from targeted regions of the skin offer the potential to enable analysis of temporal variations in electrolyte balance and biomarker concentration throughout a period of interest. Current methods that rely on absorbent pads taped to the skin do not offer the ease of use in sweat capture needed for quantitative tracking; emerging classes of electronic wearable sweat analysis systems do not directly manage sweat-induced fluid flows for sample isolation. Here, a thin, soft, "skin-like" microfluidic platform is introduced that bonds to the skin to allow for collection and storage of sweat in an interconnected set of microreservoirs. Pressure induced by the sweat glands drives flow through a network of microchannels that incorporates capillary bursting valves designed to open at different pressures, for the purpose of passively guiding sweat through the system in sequential fashion. A representative device recovers 1.8 mu L volumes of sweat each from 0.8 min of sweating into a set of separate microreservoirs, collected from 0.03 cm(2) area of skin with approximately five glands, corresponding to a sweat rate of 0.60 mu L min(-1) per gland. Human studies demonstrate applications in the accurate chemical analysis of lactate, sodium, and potassium concentrations and their temporal variations.