PROLONGATION OF THE YEAST LIFE-SPAN BY THE V-HA-RAS ONCOGENE
PROLONGATION OF THE YEAST LIFE-SPAN BY THE V-HA-RAS ONCOGENE
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DOI：
10.1111/j.1365-2958.1990.tb00568.x
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发表时间：
1990-12-01
影响因子：
3.6
通讯作者：
JAZWINSKI, SM
中科院分区：
文献类型：
--
作者：
CHEN, JB;SUN, J;JAZWINSKI, SM
芽殖酵母的寿命是有限的，这是由细胞分裂的次数决定的。某些基因的表达模式在人的一生中以一种特定的方式发生变化，这意味着衰老过程中至少有一些表现是受基因调控的。现在已经确定，酵母中RAS癌基因的控制表达增加了这种生物体的寿命，这表明，相反，单个基因活性的明确改变可以延长这种生物体的寿命。结果表明，RAS的表达在延长寿命和抑制生长之间存在平衡。由于酵母中RAS的同源物具有整合细胞代谢与细胞周期的功能，这些研究提出了这种整合功能也可能适用于生命周期中连续细胞周期的协调的可能性。
The budding yeast Saccharomyces cerevisiae has a finite life span that is defined by the number of times the cell divides. The patterns of expression of certain genes change in a specific manner during the life span, implying that at least some of the manifestations of the ageing process are subject to gene regulation. It has now been determined that the controlled expression of the RAS oncogene in yeast increases the longevity of this organism, indicating that, conversely, a defined alteration in the activity of a single gene can extend this organism's life span. The results suggest that there is a balance between life-span extension and growth arrest when RAS is expressed. Inasmuch as the homologues of RAS in yeast function to integrate cell metabolism with the cell cycle, these studies raise the possibility that this integrative function may also apply to the co-ordination of successive cell cycles during the life span.