Mineralized Collagen: Rationale, Current Status, and Clinical Applications.
Mineralized Collagen: Rationale, Current Status, and Clinical Applications.
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矿化胶原蛋白：基本原理、现状和临床应用
DOI：
10.3390/ma8084733
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发表时间：
2015-07-24
期刊：
影响因子：
--
通讯作者：
Cui FZ
中科院分区：
文献类型：
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作者：
Qiu ZY;Cui Y;Tao CS;Zhang ZQ;Tang PF;Mao KY;Wang XM;Cui FZ
本文就矿化胶原蛋白体外矿化的基本原理、制备方法及临床应用作一综述。天然矿化胶原蛋白的基本原理和相关的矿化过程已经研究了几十年。基于对天然矿化胶原蛋白及其形成过程的了解，人们尝试制备在成分和结构上都与天然矿化胶原蛋白相似的仿生材料。迄今为止，许多基于矿化胶原蛋白原理的骨替代材料已经被开发出来，其中一些已经商业化并得到了监管机构的批准。矿化胶原蛋白的临床效果对推进相关医疗器械产品的评价和改进具有重要意义。已经报道了一些具有代表性的临床病例，并且目前有许多研究组正在进行更多的临床应用和长期随访。
This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups.