SELF-STIMULATION PATHWAYS IN MONKEY, MACACA-MULATTA
SELF-STIMULATION PATHWAYS IN MONKEY, MACACA-MULATTA
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DOI：
10.1016/0014-4886(71)90115-4
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发表时间：
1971-01-01
影响因子：
5.3
通讯作者：
HUANG, YH
中科院分区：
文献类型：
--
作者：
ROUTTENBERG, A;GARDNER, EL;HUANG, YH
九只恒河猴每只都在假定的颅内自刺激（ICSS）部位植入了多个电极。在 3-4 个月的时间里，每只动物仅使用一个支持 ICSS 的电极放置。这在一个大脑部位建立了对大脑刺激的稳定行为反应。这一过程降低了对一个部位的大脑刺激做出的反应与第二个部位的大脑刺激相关的可能性。在这些稳定的 ICSS 位点进行损伤，并使用 Fink-Heimer 方法研究这些位点的顺行变性。 ICSS 基因座的绘图表明，内囊的内侧尖端支持非常强烈的自我刺激水平。 ICSS 部位的病变产生退行性病变，继而出现丘脑下脚。由于该束位于内囊内侧尖端的位置，因此它被强烈认为是参与自我刺激的一条主要通路。髓纹以及较小程度的终纹也受到影响。末期变性银浸渍所涉及的主要互连结构是丘脑和眶额皮质的背内侧核。我们尝试将这些发现与啮齿动物的内侧前脑束 ICSS 系统联系起来。
Nine rhesus monkeys each had several electrodes implanted in presumed intracranial self-stimulation (ICSS) sites. For 3–4 months, only a single electrode placement supporting ICSS was used in each animal. This established a stable behavioral response to brain stimulation at one brain locus. This procedure reduced the possibility that the response made to brain stimulation at one locus would be related to brain stimulation at a second locus. Lesions were made at these stable ICSS sites and orthograde degeneration from these sites was studied using the Fink-Heimer method. Mapping of ICSS loci indicated that the medial tip of the internal capsule supported very intense levels of self-stimulation. Lesions at ICSS sites produced degeneration which followed the inferior thalamic peduncle. Because of the position of this tract in the medial tip of the internal capsule, it was strongly implicated as one major pathway involved in self-stimulation. The stria medullaris and, to a lesser extent, the stria terminalis were also involved. The major interconnecting structures implicated by silver impregnation of terminal degeneration were the dorsomedial nucleus of the thalamus and the orbitofrontal cortex. An attempt was made to relate these findings to the medial forebrain bundle ICSS system in the rodent.