Default mode network subsystem alterations in obsessive-compulsive disorder
Default mode network subsystem alterations in obsessive-compulsive disorder
复制标题
DOI：
10.1192/bjp.bp.113.137380
复制
发表时间：
2014-11-01
影响因子：
10.5
通讯作者：
Kaufmann, Christian
中科院分区：
文献类型：
--
作者：
Beucke, Jan C.;Sepulcre, Jorge;Kaufmann, Christian
背景尽管强迫症（OCD）的神经生物学模型传统上强调皮质纹状体脑区的中心作用，但对默认模式网络完整性的研究已经引起了越来越多的兴趣，但产生了相互矛盾的结果。AimsTo解决这些不一致的发现，通过检查默认模式网络子系统的完整性在强迫症。方法比较种子为基础的休息，使用功能性磁共振成像（functional magnetic resonance imaging，FMRI）对46例强迫症患者和46例对照者的11个默认模式网络成分的功能连接进行了研究。在控制了情感性精神障碍的药物治疗状况和生活史后仍有显著性差异。此外，更大的自我子系统和显着性和注意力网络之间的连接observed.ConclusionsResults表明，强迫症的人显示异常的神经系统以前与自我参考，在健康的个人处理，并建议需要检查这个默认模式的网络子系统和其他大型网络之间的动态相互作用，在这种疾病。
BackgroundAlthough neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results.AimsTo resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD.MethodComparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging.ResultsSignificantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed.ConclusionsResults indicate that people with OCD show abnormalities in a neural system previously associated with self-referential, processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.