'Yin and Yang' in inflammation: duality in innate immune cell function and tumorigenesis
'Yin and Yang' in inflammation: duality in innate immune cell function and tumorigenesis
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DOI：
10.1517/14712598.8.10.1461
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发表时间：
2008-10-01
影响因子：
4.6
通讯作者：
Khatami, Mahin
中科院分区：
文献类型：
--
作者：
Khatami, Mahin
背景：急性炎症过程的两个阶段是细胞凋亡（“阴”）和伤口愈合或消退（“阳”）。炎症保护宿主免受有害因素的侵害。目的/方法：讨论具有“杀肿瘤”和/或“致瘤”特性的先天性免疫细胞在炎症诱导的免疫系统功能障碍和慢性炎症性疾病、增生、癌前病变/瘤形成或肿瘤和血管生成的发生中的多效性作用。结果/结论：细胞凋亡和伤口愈合之间的平衡失去维持以及组织中死亡和生长因子的共存可能会产生“免疫反应失配”的积累，从而产生“免疫混乱”。未解决的炎症在慢性炎症和自身免疫性疾病以及癌症的发生中起作用。在靶组织或癌症微环境中免疫功能障碍的发展阶段，识别累积的“不匹配”死亡和生长因子为这些疾病的诊断、预防和治疗的未来研究提出了挑战和机遇。
Background: The two stages of the acute inflammatory process are apoptosis ('Yin') and wound healing or resolution ('Yang'). Inflammation defends the host against unwanted elements. Objective/methods: To present a discussion of pleicitropic roles of innate immune cells possessing 'tumoricidal' and/or 'tumorigenic' properties in inflammation-induced dysfunction of the immune system and the genesis of chronic inflammatory diseases, hyperplasia, precancer/neoplasia or tumor and angiogenesis. Results/conclusions: Loss of maintenance of the balance between apoptosis and wound healing and co-existence of death and growth factors in tissues could create 'immunological chaos' with accumulation of 'immune response mismatches'. Unresolved inflammation plays a role in the genesis of chronic inflammatory and autoimmune diseases and cancer. Identification of accumulated 'mismatched' death and growth factors during the developmental phases of immune dysfunction in target tissues or cancer microenvironment presents challenges and opportunities for future studies on diagnosis, prevention and therapy of these diseases.