In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis
In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis
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DOI：
10.1128/aac.01310-06
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发表时间：
2007-03-01
影响因子：
4.9
通讯作者：
Palittapongarnpim, Prasit
中科院分区：
文献类型：
--
作者：
Hongmanee, Poonpilas;Rukseree, Karnolchanok;Palittapongarnpim, Prasit
本文研究了氯羟喹（5-氯喹啉-8-醇）对9株结核分枝杆菌标准株和150株结核分枝杆菌临床分离株的体外抗菌活性。MIC范围为0.062 - 0.25 μ g/ml。MIC_（1）和MIC_（0）分别为0.125和0.25 μ g/ml。这些结果表明，氯氧喹表现出良好的抗结核活性，即使对多重耐药菌株。
The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 mu g/ml. The MIC,, and MIC,0 were 0.125 and 0.25 mu g/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.