Biomarkers for cognitive impairment and dementia in elderly people.
Biomarkers for cognitive impairment and dementia in elderly people.
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DOI：
10.1016/s1474-4422(08)70162-5
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发表时间：
2008-08
期刊：
影响因子：
48
通讯作者：
Montine, Thomas J.
中科院分区：
文献类型：
--
作者：
Sonnen, Joshua A.;Montine, Kathleen S.;Quinn, Joseph F.;Kaye, Jeffrey A.;Breitner, John C. S.;Montine, Thomas J.
老年人痴呆症大流行的威胁迫在眉睫，这突出表明迫切需要开发和验证可用于识别疾病的临床前和前驱阶段以及完全症状性痴呆的生物标志物。虽然预测的危险因素和相关的神经影像学措施将在这些努力中发挥重要作用，本综述介绍了最近的进展，发现，验证和标准化的分子生物标志物-小分子和大分子，其浓度在大脑或生物液体可以帮助诊断在不同阶段的更常见的痴呆症疾病和评估疾病进展和治疗反应。一种有效结合来自风险因素评估、神经影像学测量和生物标志物的独立信息的方法可能很快就会指导临床医生对老年人认知障碍进行早期诊断和管理。
The threat of a looming pandemic of dementia in elderly people highlights the compelling need for the development and validation of biomarkers that can be used to identify pre-clinical and prodromal stages of disease in addition to fully symptomatic dementia. Although predictive risk factors and correlative neuroimaging measures will have important roles in these efforts, this Review describes recent progress in the discovery, validation, and standardization of molecular biomarkers – small molecules and macromolecules whose concentration in brain or biological fluids can aid in diagnosis at different stages of the more common dementing diseases and in the assessment of disease progression and response to therapeutics. An approach that efficiently combines independent information from risk factor assessment, neuroimaging measures, and biomarkers may soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people.