A further leap of improvement in tertiary structure prediction in CASP13 prompts new routes for future assessments
A further leap of improvement in tertiary structure prediction in CASP13 prompts new routes for future assessments
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DOI：
10.1002/prot.25787
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发表时间：
2019-08-07
影响因子：
2.9
通讯作者：
Dal Peraro, Matteo
中科院分区：
文献类型：
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作者：
Abriata, Luciano A.;Tamo, Giorgio E.;Dal Peraro, Matteo
我们在结构预测的关键评估第13轮（CASP 13）中对硬目标的三级结构预测进行了评估。分析包括：（a）通过对每个评价单元（EU）的模型进行评分辅助目视检查，分配和讨论最佳模型;（B）对该评价和全局评分产生的预测因子进行排名;以及（c）对蛋白质结构预测的进展、最新技术水平和当前限制进行评价。我们见证了从CASP 11到CASP 12所观察到的进展，三级结构预测有了相当大的改进，（a）顶级模型达到了骨干RMSD
We present our assessment of tertiary structure predictions for hard targets in Critical Assessment of Structure Prediction round 13 (CASP13). The analysis includes (a) assignment and discussion of best models through scores-aided visual inspection of models for each evaluation unit (EU); (b) ranking of predictors resulting from this evaluation and from global scores; and (c) evaluation of progress, state of the art, and current limitations of protein structure prediction. We witness a sizable improvement in tertiary structure prediction building on the progress observed from CASP11 to CASP12, with (a) top models reaching backbone RMSD