Integrated analysis of pseudogene RP11-564D11.3 expression and its potential roles in hepatocellular carcinoma
Integrated analysis of pseudogene RP11-564D11.3 expression and its potential roles in hepatocellular carcinoma
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假基因RP11-564D11.3表达的整合分析及其在肝细胞癌中的潜在作用
DOI：
10.2217/epi-2018-0152
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发表时间：
2019-02-01
期刊：
影响因子：
3.8
通讯作者：
Hao, Xiaojiang
中科院分区：
文献类型：
--
作者：
Song, Hui;Yang, Jue;Hao, Xiaojiang
目的：我们的目的是找出差异表达的假基因，并探讨其在肿瘤发生中的功能作用。材料和方法：在这里，我们确定失调的假基因，分析它们的预后价值，并通过来自公共组学库的假基因-miRNA-mRNA网络研究它们的潜在功能。结果如下：我们鉴定了16个频繁上调的假基因，其中RP 11 - 564 D11.3的高表达水平与7种人类癌症的总生存率显著相关。RP 11 -564D11.3与癌症中的通路、PI 3 K-Akt信号通路和神经营养因子信号通路密切相关。进一步的研究表明，RP 11 - 564 D11.3在肝细胞癌中作为竞争性内源性RNA通过靶向VEGFA发挥作用。结论：RP 11 -564D11.3是一种新的肝癌生物标志物和潜在的治疗靶点。
Aim: We aim to identify differentially expressed pseudogenes and investigate their functional roles in carcinogenesis. Materials & methods: Here, we identify dysregulated pseudogenes, analyze their prognostic values and investigate their potential functions through pseudogene-miRNA-mRNA network from public -omics repositories. Results: We identified 16 frequently upregulated pseudogenes among which high expression levels of RP11-564D11.3 was significantly associated with poor overall survival in seven types of human cancers. RP11-564D11.3 was strongly correlated with pathways in cancer, PI3K-Akt signaling pathway and the neurotrophin signaling pathway. Further studies revealed that RP11-564D11.3 functions as a competitive endogenous RNA through targeting VEGFA in hepatocellular carcinoma. Conclusion: Our findings suggest RP11-564D11.3 as a novel biomarker and therapeutic potential target against hepatocellular carcinoma.