Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS
Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS
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DOI：
10.1186/cc306
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发表时间：
1999-01-01
期刊：
影响因子：
15.1
通讯作者：
Schmidt, J
中科院分区：
文献类型：
--
作者：
Meisner, M;Tschaikowsky, K;Schmidt, J
目的：分析不同严重程度的多器官功能障碍综合征（MODS）和全身炎症患者中降钙素原（PCT）血浆浓度与C反应蛋白（CRP）的关系。患者和方法：对40名患有全身炎症和连续MODS超过15年的患者进行PCT、CRP、脓毒症相关器官衰竭评估（SOFA）评分、急性生理学、年龄、慢性健康评估（APACHE）II评分和生存率评估结果：较高的 SOFA 评分水平与显着较高的 PCT 血浆浓度相关（SOFA 7-12：PCT 2.62 ng/ml，SOFA 19-24：PCT 15.22 ng/ml）（中位数），而无论观察到的评分如何，CRP 都会升高（SOFT 7-12：CRP 131 mg/l，SOFT 19-24：CRP 135 mg/l）。未存活患者的 PCT 最初与存活者没有差异，但在发病后第四天后显着升高，而 CRP 在整个观察期间两组之间没有差异。结论：多器官功能障碍综合征期间 PCT 浓度的测量比 CRP 提供了更多关于疾病严重程度和病程的信息。关于未来研究中 PCT 与各自评分系统的强相关性，我们建议在比较不同类型疾病之间的 PCT 浓度时，也评估炎症和 MODS 的严重程度。
Objectives: The relation of procalcitonin (PCT) plasma concentrations compared with C-reactive protein (CRP) was analyzed in patients with different severity of multiple organ dysfunction syndrome (MODS) and systemic inflammation.Patients and methods: PCT, CRP, the sepsis-related organ failure assessment (SOFA) score, the Acute Physiology, Age, Chronic Health Evaluation (APACHE) II score and survival were evaluated in 40 patients with systemic inflammation and consecutive MODS over a period of 15 days.Results: Higher SOFA score levels were associated with significantly higher PCT plasma concentrations (SOFA 7-12: PCT 2.62 ng/ml, SOFA 19-24: PCT 15.22 ng/ml) (median), whereas CRP was elevated irrespective of the scores observed (SOFT 7-12: CRP 131 mg/l, SOFT 19-24: CRP 135 mg/l). PCT of non-surviving patients was initially not different from that of survivors but significantly increased after the fourth day following onset of the disease, whereas CRP was not different between both groups throughout the whole observation period.Conclusions: Measurement of PCT concentrations during multiple organ dysfunction syndrome provides more information about the severity and the course of the disease than that of CRP. Regarding the strong association of PCT and the respective score systems in future studies we recommend evaluation also of the severity of inflammation and MODS when PCT concentrations were compared between different types of disease.