Effect of excessive secretion of growth hormone on tissues of the rat, with particular reference to the heart and skeletal muscle.
Effect of excessive secretion of growth hormone on tissues of the rat, with particular reference to the heart and skeletal muscle.
复制标题
生长激素过度分泌对大鼠组织的影响，特别是心脏和骨骼肌。
DOI：
10.1677/joe.0.0850075
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Jenkins
中科院分区：
文献类型：
--
作者：
R. A. Prysor;J. Jenkins
大鼠垂体瘤的GH 3细胞系，分泌生长激素（GH），诱导生长在Wistar-Furth大鼠和GH的长期过度分泌对各种器官的影响进行了研究。与对照动物相比，荷瘤动物的总体重增加超过100%，并且存在广泛的内脏肿大，尤其影响肝脏、肾脏、脾脏和肾上腺。心脏也被放大了很多。过度生长激素对骨骼肌的影响是不均匀的，并使用组织化学技术，它被发现，1型肌纤维的大小增加到最大程度，而纤维类型2A不受影响。心脏和骨骼肌中的DNA合成也在荷瘤动物中增加。切除肿瘤后，大部分器官的大小出现了相当大的回归，尽管心脏肥大受GH血浆水平恢复正常的影响最小。得出的结论是，动物轴承GH 3细胞肿瘤提供了一个有用的实验模型的研究肢端肥大症的组织变化。
Rat pituitary tumours of the GH3 cell line, secreting growth hormone (GH), were induced to grow in Wistar-Furth rats and the effect of prolonged excessive secretion of GH on various organs was investigated. Total body weight of the tumour-bearing animals increased by over 100% compared with control animals and there was widespread visceromegaly affecting especially the liver, kidney, spleen and adrenals. The heart was also considerably enlarged. The effects of excessive GH on skeletal muscle were not uniform and, using a histochemical technique, it was found that the size type 1 muscle fibres was increased to the greatest extent whereas fibre type 2A was unaffected. Synthesis of DNA in the heart and skeletal muscle was also increased in tumour-bearing animals. Removal of the tumours was followed by a considerable regression in the size of most organs, although hypertrophy of the heart was affected least by a return to normal plasma levels of GH. It was concluded that animals bearing GH3 cell tumours provide a useful experimental model for the study of the tissue changes in acromegaly.