SCHISTOSOMA-JAPONICUM - AN ULTRAVIOLET-ATTENUATED CERCARIAL VACCINE APPLICABLE IN THE FIELD FOR WATER-BUFFALOS
SCHISTOSOMA-JAPONICUM - AN ULTRAVIOLET-ATTENUATED CERCARIAL VACCINE APPLICABLE IN THE FIELD FOR WATER-BUFFALOS
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DOI：
10.1016/0014-4894(90)90012-2
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发表时间：
1990-07-01
影响因子：
2.1
通讯作者：
RUPPEL, A
中科院分区：
文献类型：
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作者：
SHI, YE;JIANG, CF;RUPPEL, A
水牛用10000条日本血吸虫尾蚴进行了3次免疫接种，这些尾蚴是用紫外线（uv）以400微瓦·分钟/平方厘米的剂量照射的。照射是在中国湖北省农村地区用廉价、简易且便携的设备进行的。对6头免疫接种的水牛和6头未免疫的对照水牛进行了1000条未处理尾蚴的攻击感染，同时有2头免疫接种的动物未接受攻击。在攻击6周后实验终止。对照动物体重减轻，每克肝脏平均有110条虫体和37个虫卵。免疫接种的动物在攻击后体重增加，对日本血吸虫感染产生了89%的抵抗力。由于日本血吸虫病如今在中国主要通过家畜传播，一种用于牛的紫外线减毒尾蚴疫苗可能有助于控制这种疾病。
Water buffaloes were vaccinated three times with 10,000 Schistosoma japonicum cercariae irradiated with ultraviolet (uv) light at a dose of 400 .mu.W .cntdot. min/cm2. The irradiation was performed with cheap, simple, and portable equipment in a rural area of Hubei Province (People''s Republic of China). A challenge infection of 1000 untreated cercariae was given to six vaccinated and six naive control buffaloes, while two vaccinated animals were not challenged. The experiment was terminated 6 weeks after the challenge. Control animals had lost body weight and harbored a mean of 110 worms and 37 eggs per gram of liver. The vaccinated animals gained weight after the challenge and developed 89% resistance to infection with S. japonicum. Since schistosomiasis japonica is nowadays transmitted in China predominantly by domestic livestock, a uv-attenuated cercarial vaccine for bovines may contribute to the control of this disease.