Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery
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DOI：
10.3390/pharmaceutics12030213
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发表时间：
2020-03-01
期刊：
影响因子：
5.4
通讯作者：
Coclite, Anna Maria
中科院分区：
文献类型：
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作者：
Decandia, Gianfranco;Palumbo, Fabio;Coclite, Anna Maria
通过引发化学气相沉积将由甲基丙烯酸和乙二醇二甲基丙烯酸酯的共聚物组成的涂层沉积在庆大霉素薄膜上，目的是控制药物释放。通过电导测量和紫外-可见荧光光谱法监测水中庆大霉素的释放。聚合物化学成分（特别是其交联密度）的影响已被研究作为控制引发的化学气相沉积（iCVD）涂层在水中的溶胀行为的工具，从而控制其释放药物的能力。在纤维素涂层基质上针对金黄色葡萄球菌和铜绿假单胞菌的琼脂扩散试验和微肉汤稀释试验证实，尽管庆大霉素的释放不完全，但涂层释放的药物的抗菌活性得以保留。
A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.