Citral is a new inducer of caspase-3 in tumor cell lines
Citral is a new inducer of caspase-3 in tumor cell lines
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DOI：
10.1055/s-2005-864146
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发表时间：
2005-05-01
期刊：
影响因子：
2.7
通讯作者：
Ofir, R
中科院分区：
文献类型：
--
作者：
Dudai, N;Weinstein, Y;Ofir, R
柠檬醛，3,7-二甲基-2,6-八烯二烯-1-al，是从几种草本植物中提取的柠檬香味精油的关键成分，如柠檬草（Cymbopogon citratus）、茉莉（melissa officinalis）、马鞭草（verbena officinalis），被用作食品添加剂和化妆品中的香料。在本研究中，我们探讨了柠檬醛的抗癌潜力及其作用方式。44.5 μ M的浓度，相当于一杯1克柠檬草制成的茶中柠檬醛的浓度，诱导了几种造血癌细胞的凋亡。细胞凋亡伴随着DNA断裂和caspase-3催化活性的诱导。在DNA断裂和caspase-3酶活性方面，将柠檬醛（22.25 μ M）与staurosporine （0.7 μ M）等参考化合物进行了比较。柠檬醛的凋亡作用依赖于α、β -不饱和醛基团。
Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 mu M, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 mu M) was compared to a reference compound like staurosporine (0.7 mu M), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the alpha,beta-unsaturated aldehyde group.