Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome
Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome
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DOI：
10.1183/09031936.03.00089902
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发表时间：
2003-07-01
影响因子：
24.3
通讯作者：
Racineux, JL
中科院分区：
文献类型：
--
作者：
Meslier, N;Gagnadoux, F;Racineux, JL
本横断面研究的目的是评估临床上出现不同程度阻塞性睡眠呼吸暂停综合征（OSAS）的男性人群中2型糖尿病和糖耐量减低（IGT）的发生率，并分析OSAS与葡萄糖-胰岛素代谢的关系。通过测量空腹和负荷后血糖和血浆胰岛素进行耐受性试验。胰岛素敏感性以空腹血糖与空腹胰岛素的比值来评价，494例患者被诊断为OSAS，101例患者为非呼吸暂停打鼾。2型糖尿病在OSAS患者中占30.1%，在无呼吸暂停打鼾者中占13.9%。OSAS患者中IGT的检出率为20.0%，非呼吸暂停打鼾者中IGT的检出率为13.9%。空腹和负荷后血糖随睡眠呼吸暂停严重程度的增加而升高。胰岛素敏感性随着睡眠呼吸暂停严重程度的增加而降低。除了体重指数和年龄外，呼吸暂停/低通气指数独立影响负荷后血糖和胰岛素敏感性。作者得出结论，在临床样本中，阻塞性睡眠呼吸暂停综合征与高频率的2型糖尿病和糖耐量受损相关。睡眠呼吸障碍和葡萄糖-胰岛素代谢受损之间的关系与肥胖和年龄无关。
The aim of this cross-sectional study was to evaluate the frequency of type-2 diabetes and impaired glucose tolerance (IGT) in a large clinic-based male population presenting various degrees of obstructive sleep apnoea syndrome (OSAS) and to analyse the relationship between OSAS and glucose-insulin metabolism.Male patients (n=595) with suspected OSAS underwent both nocturnal polysomnography and a 2-h oral glucose-tolerance test with measurements of fasting and postload blood glucose and plasma insulin. Insulin sensitivity was evaluated by the ratio of fasting glucose to fasting insulin.OSAS was diagnosed in 494 patients, while 101 patients were nonapnoeic snorers. Type-2 diabetes was present in 30.1% of OSAS patients and 13.9% of nonapnoeic snorers. IGT was diagnosed in 20.0% of OSAS patients and 13.9% of nonapnoeic snorers. Fasting and postload blood glucose increased with severity of sleep apnoea. Insulin sensitivity decreased with increasing severity of sleep apnoea. In addition to body mass index and age, the apnoea/hypopnoea index independently influenced postload blood glucose and insulin sensitivity.The authors conclude that in a clinic-based sample of patients, obstructive sleep apnoea syndrome is associated with a high frequency of type-2 diabetes and impaired glucose tolerance. The relationship between sleep-disordered breathing and impaired glucose-insulin metabolism is independent of obesity and age.