Plasmodium falciparum:: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
Plasmodium falciparum:: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
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DOI：
10.1016/j.exppara.2005.12.003
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发表时间：
2006-05-01
影响因子：
2.1
通讯作者：
Duffy, Patrick E.
中科院分区：
文献类型：
--
作者：
Fried, Michal;Domingo, Gonzalo J.;Duffy, Patrick E.
隔离在胎盘中的恶性疟原虫寄生虫与硫酸软骨素 A (CSA) 分子结合。妇女在怀孕期间获得了抑制寄生虫粘附到 CSA 的抗体，从而对疟疾产生了抵抗力，这表明针对胎盘疟疾的疫苗是可行的。透明质酸 (HA) 和非免疫 IgG 也被提议作为胎盘中恶性疟原虫粘附的受体，但其作用的证据尚无定论。在这项研究中，同时评估了 CSA、HA 和 IgG 对胎盘粘附的相对贡献。在坦桑尼亚收集的胎盘寄生虫均匀地粘附在 CSA 分子上，可溶性 CSA 完全抑制了大多数样品对胎盘冷冻切片的粘附。 46 个胎盘寄生虫样本中的 3 个也粘附到固定的 HA 上，但 HA 未能抑制任何胎盘寄生虫粘附到胎盘冷冻切片上。同样，非免疫 IgG 和蛋白 A 未能抑制寄生虫样本对胎盘冷冻切片的粘附。恶性疟原虫在胎盘中的粘附似乎是一个非冗余过程，需要 CSA 作为受体。引发针对 CSA 结合寄生虫的功能性抗体的疫苗可能具有对妊娠期疟疾的抵抗力。 (c) 2006 Elsevier Inc. 保留所有权利。
Plasmodium falciparum parasites that sequester in the placenta bind to the molecule chondroitin sulfate A (CSA). Women become resistant to malaria during pregnancy as they acquire antibodies that inhibit parasite adhesion to CSA, suggesting that a vaccine against placental malaria is feasible. Hyaluronic acid (HA) and non-immune IgG have also been proposed as receptors for P. falciparum adhesion in the placenta, but evidence for their roles is inconclusive. In this study, CSA, HA, and IgG were simultaneously assessed for their relative contributions to placental adhesion. Placental parasites collected in Tanzania uniformly adhered to the molecule CSA, and soluble CSA completely inhibited adhesion of most samples to placental cryosections. Three of 46 placental parasite samples also adhered to immobilized HA, but HA failed to inhibit adhesion of any placental parasites to placental cryosections. Similarly, non-immune IgG and protein A failed to inhibit adhesion of parasite samples to placental cryosection. P. falciparum adhesion in the placenta appears to be a non-redundant process that requires CSA as a receptor. Vaccines that elicit functional antibodies against CSA-binding parasites may confer resistance to pregnancy malaria. (c) 2006 Elsevier Inc. All rights reserved.