Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta
Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta
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DOI：
10.1016/j.neurobiolaging.2019.11.016
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发表时间：
2020-03-01
影响因子：
4.2
通讯作者：
Hu, Xiaoping
中科院分区：
文献类型：
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作者：
Langley, Jason;Hussain, Sana;Hu, Xiaoping
蓝斑(LC)和黑质致密部(SNPC)随着正常年龄的增长而退化，但关于这些变化如何在MRI图像中表现出来，或者这些标记物是否可以预测认知方面的情况，我们知之甚少。在这里，我们使用高分辨率扩散加权MRI来研究年轻人和老年人LC和SNPC的微观结构和成分变化，以及它们与认知的关系。在LC中，与年轻组相比，年长组的平均弥散率和径向弥散率显著降低，但分数各向异性显著增加。我们观察到，在老年人队列中，LC平均值、轴向和径向扩散系数的降低与检查认知的指标(Rey听觉语言学习测试延迟回忆)之间存在显著的相关性。这一观察结果表明，LC参与了认知能力的保持。此外，我们观察到SNPC中的铁沉积发生在生命早期，并在正常老化过程中持续。(C)2019 Elsevier Inc.保留所有权利。
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young and older adult cohorts, as well as their relationship with cognition. In LC, the older cohort exhibited a significant reduction in mean and radial diffusivity, but a significant increase in fractional anisotropy compared with the young cohort. We observed a significant correlation between the decrease in LC mean, axial, and radial diffusivities and measures examining cognition (Rey Auditory Verbal Learning Test delayed recall) in the older adult cohort. This observation suggests that LC is involved in retaining cognitive abilities. In addition, we observed that iron deposition in SNpc occurs early in life and continues during normal aging. (C) 2019 Elsevier Inc. All rights reserved.