Overexpression of cytotoxic proteins correlates with liver function impairment in patients with drug reaction with eosinophilia and systemic symptoms (DRESS)
Overexpression of cytotoxic proteins correlates with liver function impairment in patients with drug reaction with eosinophilia and systemic symptoms (DRESS)
复制标题
细胞毒性蛋白的过度表达与伴有嗜酸性粒细胞增多和全身症状的药物反应患者的肝功能损害相关（DRESS）。
DOI：
10.1684/ejd.2017.3211
复制
发表时间：
2018-01-01
影响因子：
2.5
通讯作者：
Luo, Xiaoqun
中科院分区：
文献类型：
--
作者：
Yang, Fanping;Chen, Sheng-an;Luo, Xiaoqun
Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterised by skin rash and multivisceral involvement. The liver is the organ most frequently affected and the degree of liver function impairment often correlates with the mortality rate of DRESS. Objective: We aimed to examine the expression of cytotoxic proteins, including soluble Fas ligand (sFasL), TNF-alpha, granulysin, perforin, and granzyme B in the sera and skin lesions of patients with DRESS and evaluate their clinical significance. Materials & methods: Our cohort consisted of 21 patients with DRESS and control groups including 39 patients with Stevens-Johnson syndrome/toxic epidermal necrolysis, 21 patients with maculopapular eruption, and 29 normal controls. Concentrations of cytotoxic proteins in the sera were measured using enzyme-linked immunosorbent assays. Tissue samples were also obtained from typical skin lesions, and immunohistochemical staining was conducted to assess the local expression of cytotoxic proteins. Results: We found that sFasL and granzyme B were significantly over-expressed in the sera of DRESS patients compared to normal controls. Furthermore, the levels of sFasL, perforin, and granzyme B significantly correlated with the serum level of liver enzymes in DRESS patients. Immunohistochemical examination also showed overexpressed cytotoxic proteins in cutaneous DRESS lesions. Conclusions: Cytotoxic proteins may play a vital role in the pathogenesis of DRESS, and serum sFasL, perforin, and granzyme B may also be involved in liver function impairment in DRESS patients.
