Biomechanics and biophysics of cancer cells
Biomechanics and biophysics of cancer cells
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DOI：
10.1016/j.actamat.2007.04.022
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发表时间：
2007-07-01
期刊：
影响因子：
9.4
通讯作者：
Suresh, Subra
中科院分区：
文献类型：
--
作者：
Suresh, Subra
在过去十年中，对细胞和亚细胞结构的生物力学和生物物理性质的变化如何影响人类疾病的发生和发展以及如何受人类疾病的发生和发展影响的研究有了实质性的增长。本文概述了迅速扩大的，新生的研究领域，涉及癌细胞的生物力学和生物物理学。审查开始与一些关键的观察癌细胞的生物学和肌动蛋白微丝的作用，中间丝和微管生物聚合物细胞骨架成分在影响细胞力学，运动，分化和肿瘤转化。为了设置场景的机械讨论之间的连接的改变，亚细胞结构，伴随着细胞变形能力，细胞粘附，迁移，侵袭和肿瘤转移的变化，调查提出了各种定量的机械和物理测定提取的弹性和粘弹性变形的癌细胞。然后对不同类型癌症的细胞力学文献中的结果进行综述。代表性的案例研究，说明如何化学诱导的细胞骨架的变化，生物力学反应和信号从细胞内区域的行为与细胞外基质的化学力学环境和分子致瘤信号传导途径，以实现恶性转化。研究结果表明，癌症药物和化疗方案诱导的细胞骨架结构的变化可以显着影响细胞力学和疾病状态。通过实验证据推断，更好地理解癌细胞变形性的机制及其与细胞外物理、化学和生物环境的相互作用为疾病诊断、药理学、治疗学和药物功效测定的重大新发展提供了巨大的潜力。(c)2007 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
The past decade has seen substantial growth in research into how changes in the biomechanical and biophysical properties of cells and subcellular structures influence, and are influenced by, the onset and progression of human diseases. This paper presents an overview of the rapidly expanding, nascent field of research that deals with the biomechanics and biophysics of cancer cells. The review begins with some key observations on the biology of cancer cells and on the role of actin microfilaments, intermediate filaments and microtubule biopolymer cytoskeletal components in influencing cell mechanics, locomotion, differentiation and neoplastic transformation. In order to set the scene for mechanistic discussions of the connections among alterations to subcellular structures, attendant changes in cell deformability, cytoadherence, migration, invasion and tumor metastasis, a survey is presented of the various quantitative mechanical and physical assays to extract the elastic and viscoelastic deformability of cancer cells. Results available in the literature on cell mechanics for different types of cancer are then reviewed. Representative case studies are presented next to illustrate how chemically induced cytoskeletal changes, biomechanical responses and signals from the intracellular regions act in concert with the chemomechanical environment of the extracellular matrix and the molecular tumorigenic signaling pathways to effect malignant transformations. Results are presented to illustrate how changes to cytoskeletal architecture induced by cancer drugs and chemotherapy regimens can significantly influence cell mechanics and disease state. It is reasoned through experimental evidence that greater understanding of the mechanics of cancer cell deformability and its interactions with the extracellular physical, chemical and biological environments offers enormous potential for significant new developments in disease diagnostics, prophylactics, therapeutics and drug efficacy assays. (c) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.