Optimized dose regimen for whole-body FDG-PET imaging.
Optimized dose regimen for whole-body FDG-PET imaging.
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DOI：
10.1186/2191-219x-3-63
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发表时间：
2013-08-12
期刊：
影响因子：
3.2
通讯作者：
van Dalen JA
中科院分区：
文献类型：
--
作者：
de Groot EH;Post N;Boellaard R;Wagenaar NR;Willemsen AT;van Dalen JA
欧洲核医学协会的全身氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）程序指南规定了与患者体重成比例的剂量。然而，临床实践显示肥胖患者的图像质量下降，表明使用与体重成比例的FDG剂量不能克服与尺寸相关的图像质量下降。本研究的目的是优化给予FDG剂量作为患者的体重或不同的患者依赖性参数的函数，提供更恒定质量的全身FDG-PET图像。使用给药剂量和体重之间的线性关系，在两台PET/计算机断层扫描仪（Biograph TruePoint和Biograph mCT，Siemens）上进行FDG-PET成像。通过102例体重为46至130 kg的患者肝脏的信噪比（SNR）评估图像质量。此外，最好的相关患者依赖性参数的推导，并确定一个优化的FDG剂量方案。在42例新患者中，在Biograph TruePoint系统上验证了该优化剂量方案。此外，通过模拟研究验证了这一关系，在该研究中，不同体重的患者被模拟为圆柱体模。正如预期的那样，当使用线性剂量时，两种PET系统都显示出SNR随着患者体重的增加而显著降低。当图像质量与患者相关参数拟合时，与患者体重的拟合具有最高的R2。优化剂量方案为Anew= c/t × m2，其中m为体重，t为每个床位的采集时间，c为常数（取决于扫描仪类型）。使用这种关系，SNR不再随患者的体重而变化。模拟研究证实了剂量与体质量之间的二次关系。推荐FDG剂量与患者体重之间的二次关系。模拟和临床观察结果均证实，当使用这种二次剂量方案时，图像质量在患者之间保持恒定。
The European Association of Nuclear Medicine procedure guidelines for whole-body fluorodeoxyglucose positron-emission tomography (FDG-PET) scanning prescribe a dose proportional to the patient’s body mass. However, clinical practice shows degraded image quality in obese patients indicating that using an FDG dose proportional to body mass does not overcome size-related degradation of the image quality. The aim of this study was to optimize the administered FDG dose as a function of the patient’s body mass or a different patient-dependent parameter, providing whole-body FDG-PET images of a more constant quality. Using a linear relation between administered dose and body mass, FDG-PET imaging was performed on two PET/computed tomography scanners (Biograph TruePoint and Biograph mCT, Siemens). Image quality was assessed by the signal-to-noise ratio (SNR) in the liver in 102 patients with a body mass of 46 to 130 kg. Moreover, the best correlating patient-dependent parameter was derived, and an optimized FDG dose regimen was determined. This optimized dose regimen was validated on the Biograph TruePoint system in 42 new patients. Furthermore, this relation was verified by a simulation study, in which patients with different body masses were simulated with cylindrical phantoms. As expected, both PET systems showed a significant decrease in SNR with increasing patient’s body mass when using a linear dosage. When image quality was fitted to the patient-dependent parameters, the fit with the patient’s body mass had the highest R2. The optimized dose regimen was found to be Anew= c/t × m2, where m is the body mass, t is the acquisition time per bed position and c is a constant (depending on scanner type). Using this relation, SNR no longer varied with the patient’s body mass. This quadratic relation between dose and body mass was confirmed by the simulation study. A quadratic relation between FDG dose and the patient’s body mass is recommended. Both simulations and clinical observations confirm that image quality remains constant across patients when this quadratic dose regimen is used.