Breast cancer survival in England, Norway and Sweden: a population-based comparison
Breast cancer survival in England, Norway and Sweden: a population-based comparison
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DOI：
10.1002/ijc.25264
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发表时间：
2010-12-01
影响因子：
6.4
通讯作者：
Holmberg, Lars
中科院分区：
文献类型：
--
作者：
Moller, Henrik;Sandin, Fredrik;Holmberg, Lars
几项国际研究发现，英国乳腺癌患者的存活率低于其他一些欧洲国家。我们比较了英国、挪威和瑞典国家人群的乳腺癌生存率，以确定生存率特别好或特别差的患者亚群。我们从这三个国家的国家癌症登记处提取1996-2004年诊断为乳腺癌的妇女病例。该研究包括303657例英国病例、24919例挪威病例和57512例瑞典病例。随访时间为2001-2004年。主要结局指标是按年龄和随访时间分层的5年累积相对生存率和超额死亡率。与挪威和瑞典相比，英格兰的高死亡率在确诊后的第一个月和第一年尤为明显，在年龄最大的年龄组中更为明显。与挪威患者相比，英国患者81%的额外死亡发生在诊断后的前2年。我们的研究结果强调了对症状的认识和早期发现作为提高英国乳腺癌生存率的主要策略的重要性。
Several international studies have found that survival from breast cancer is lower in the United Kingdom than in some other European countries. We have compared breast cancer survival between the national populations of England, Norway and Sweden, with a view to identifying subsets of patients with particularly good or adverse survival outcomes. We extracted cases of breast cancer in women diagnosed 1996-2004 from the national cancer registries of the 3 countries. The study comprised 303,657 English cases, 24,919 Norwegian cases and 57,512 cases from Sweden. Follow-up was in 2001-2004. The main outcome measures were 5-year cumulative relative survival and excess death rates, stratified by age and period of follow-up. In comparison with Norway and Sweden, the excess mortality in England was particularly pronounced in the first month and in the first year after diagnosis, and generally more marked in the oldest age groups. Compared with Norwegian patients, 81% of the excess deaths in the English patients occurred in the first 2 years after diagnosis. Our findings emphasise the importance of awareness of symptoms and early detection as the main strategy to improve breast cancer survival in the United Kingdom.